Patients with monogenic obesity display numerous medical features on top of hyperphagic
obesity, but no study to date has provided an exhaustive description of their semiology. Two …

The adipocyte-secreted hormone leptin and its downstream signaling mediators within the
central nervous system (Fig. 1) have been fundamental in understanding energy …

Bariatric surgery is a powerful therapy for type 2 diabetes in patients with obesity. The
mechanism of insulin sensitization by surgery has been extensively investigated in weight …

Abstract Background Transoral outlet reduction (TORe) is a safe and effective technique for
management of weight regain (WR) after Roux-en-Y Gastric Bypass (RYGB). Carriers of a …

Obesity has emerged as a critical and urgent health burden during the current global
pandemic. Among multiple genetic causes, melanocortin receptor‐4 (MC4R), involved in …

Background Roux-en-Y gastric bypass (RYGB) is associated with a high rate of type 2
diabetes (T2D) remission. Carriers of heterozygous variants in the leptin-melanocortin …

Obesity and weight regulation disorders are determined by the combined effects of genetics
and environment. Polygenic obesity results from the combination of common variants in …

The loss of function melanocortin 4-receptor (MC4R) Ile269Asn mutation has been
proposed as one of the most important genetic contributors to obesity in the Mexican …

Abstract Melanocortin-4 receptor (MC4R), expressed abundantly in the hypothalamus, is a
critical regulator of energy homeostasis, including both food intake and energy expenditure …

Objective The objective of this meta‐analysis was to quantify the overall effects of gene
mutations in the leptin‐melanocortin pathway on short‐and long‐term weight loss after …