Proteasomes are present in the cytoplasm and in the nuclei of all eukaryotic cells, however
their relative abundance within those compartments is highly variable. In the cytoplasm …

Keap1 is a negative regulator of Nrf2, a bZIP transcription factor that mediates adaptation to
oxidative stress. Previous studies suggested this negative regulation is a consequence of …

We present an integrated model of hERα-mediated transcription where both unliganded and
liganded receptors cycle on estrogen-responsive promoters. Using ChIP, FRAP, and …

Here we report the use of fluorescence recovery after photobleaching (FRAP) to examine
the intranuclear dynamics of fluorescent oestrogen receptor-α (ER). After bleaching …

The main purpose of this review is to recall for investigators-and in particular students-,
some of the early data and concepts in molecular genetics and biology that are rarely cited …

The A-type lamins have been observed to colocalize with RNA splicing factors in speckles
within the nucleus, in addition to their typical distribution at the nuclear periphery. To …

The mechanisms by which the human T-cell leukemia virus type I (HTLV-I) Tax oncoprotein
deregulates cellular signaling for oncogenesis have been extensively studied, but how Tax …

We analyse here the definition of the gene in order to distinguish, on the basis of modern
insight in molecular biology, what the gene is coding for, namely a specific polypeptide, and …

Background Lamins are major structural proteins of the nucleus and contribute to the
organization of various nuclear functions. Mutations in the human lamin A gene cause a …

'Gene'has become a vague and ill‐defined concept. To set the stage for mathematical
analysis of gene storage and expression, we return to the original concept of the gene as a …