PTPRD: neurobiology, genetics, and initial pharmacology of a pleiotropic contributor to brain phenotypes

GR Uhl, MJ Martinez - Annals of the New York Academy of …, 2019 - Wiley Online Library
Receptor‐type protein tyrosine phosphatase, receptor type D (PTPRD) has likely roles as a
neuronal cell adhesion molecule and synaptic specifier. Interest in its neurobiology and …

Astrocyte-secreted glypican 4 regulates release of neuronal pentraxin 1 from axons to induce functional synapse formation

I Farhy-Tselnicker, ACM van Casteren, A Lee… - Neuron, 2017 - cell.com
The generation of precise synaptic connections between developing neurons is critical to
the formation of functional neural circuits. Astrocyte-secreted glypican 4 induces formation of …

Role of LRRTMs in synapse development and plasticity

RT Roppongi, B Karimi, TJ Siddiqui - Neuroscience Research, 2017 - Elsevier
Leucine-rich-repeat transmembrane neuronal proteins (LRRTMs) are a family of four
synapse organizing proteins critical for the development and function of excitatory synapses …

The protein tyrosine phosphatase receptor delta regulates developmental neurogenesis

H Tomita, F Cornejo, B Aranda-Pino, CL Woodard… - Cell reports, 2020 - cell.com
PTPRD is a receptor protein tyrosine phosphatase that is genetically associated with
neurodevelopmental disorders. Here, we asked whether Ptprd mutations cause aberrant …

Canonical versus non-canonical transsynaptic signaling of neuroligin 3 tunes development of sociality in mice

T Yoshida, A Yamagata, A Imai, J Kim, H Izumi… - Nature …, 2021 - nature.com
Abstract Neuroligin 3 (NLGN3) and neurexins (NRXNs) constitute a canonical transsynaptic
cell-adhesion pair, which has been implicated in autism. In autism spectrum disorder (ASD) …

LAR receptor phospho-tyrosine phosphatases regulate NMDA-receptor responses

A Sclip, TC Südhof - Elife, 2020 - elifesciences.org
LAR-type receptor phosphotyrosine-phosphatases (LAR-RPTPs) are presynaptic adhesion
molecules that interact trans-synaptically with multitudinous postsynaptic adhesion …

SLITRK2 variants associated with neurodevelopmental disorders impair excitatory synaptic function and cognition in mice

S El Chehadeh, KA Han, D Kim, G Jang… - Nature …, 2022 - nature.com
SLITRK2 is a single-pass transmembrane protein expressed at postsynaptic neurons that
regulates neurite outgrowth and excitatory synapse maintenance. In the present study, we …

Splicing-dependent trans-synaptic SALM3–LAR-RPTP interactions regulate excitatory synapse development and locomotion

Y Li, P Zhang, TY Choi, SK Park, H Park, EJ Lee, D Lee… - Cell reports, 2015 - cell.com
Synaptic adhesion molecules regulate diverse aspects of synapse development and
plasticity. SALM3 is a PSD-95-interacting synaptic adhesion molecule known to induce …

Structural basis of SALM5-induced PTPδ dimerization for synaptic differentiation

Z Lin, J Liu, H Ding, F Xu, H Liu - Nature Communications, 2018 - nature.com
SALM5, a synaptic adhesion molecule implicated in autism, induces presynaptic
differentiation through binding to the LAR family receptor protein tyrosine phosphatases …

Structural insights into modulation and selectivity of transsynaptic neurexin–LRRTM interaction

A Yamagata, S Goto-Ito, Y Sato, T Shiroshima… - Nature …, 2018 - nature.com
Leucine-rich repeat transmembrane neuronal proteins (LRRTMs) function as postsynaptic
organizers that induce excitatory synapses. Neurexins (Nrxns) and heparan sulfate …