The generation of precise synaptic connections between developing neurons is critical to the formation of functional neural circuits. Astrocyte-secreted glypican 4 induces formation of …
Leucine-rich-repeat transmembrane neuronal proteins (LRRTMs) are a family of four synapse organizing proteins critical for the development and function of excitatory synapses …
H Tomita, F Cornejo, B Aranda-Pino, CL Woodard… - Cell reports, 2020 - cell.com
PTPRD is a receptor protein tyrosine phosphatase that is genetically associated with neurodevelopmental disorders. Here, we asked whether Ptprd mutations cause aberrant …
T Yoshida, A Yamagata, A Imai, J Kim, H Izumi… - Nature …, 2021 - nature.com
Abstract Neuroligin 3 (NLGN3) and neurexins (NRXNs) constitute a canonical transsynaptic cell-adhesion pair, which has been implicated in autism. In autism spectrum disorder (ASD) …
S El Chehadeh, KA Han, D Kim, G Jang… - Nature …, 2022 - nature.com
SLITRK2 is a single-pass transmembrane protein expressed at postsynaptic neurons that regulates neurite outgrowth and excitatory synapse maintenance. In the present study, we …
Synaptic adhesion molecules regulate diverse aspects of synapse development and plasticity. SALM3 is a PSD-95-interacting synaptic adhesion molecule known to induce …
Z Lin, J Liu, H Ding, F Xu, H Liu - Nature Communications, 2018 - nature.com
SALM5, a synaptic adhesion molecule implicated in autism, induces presynaptic differentiation through binding to the LAR family receptor protein tyrosine phosphatases …
A Yamagata, S Goto-Ito, Y Sato, T Shiroshima… - Nature …, 2018 - nature.com
Leucine-rich repeat transmembrane neuronal proteins (LRRTMs) function as postsynaptic organizers that induce excitatory synapses. Neurexins (Nrxns) and heparan sulfate …