Neuroimaging has made it possible to measure pathological brain changes associated with
Alzheimer's disease (AD) in vivo. Over the past decade, these measures have been …

Imaging has played a variety of roles in the study of Alzheimer disease (AD) over the past
four decades. Initially, computed tomography (CT) and then magnetic resonance imaging …

Currently available evidence strongly supports the position that the initiating event in
Alzheimer's disease (AD) is related to abnormal processing of β-amyloid (Aβ) peptide …

Structural imaging based on magnetic resonance is an integral part of the clinical
assessment of patients with suspected Alzheimer dementia. Prospective data on the natural …

There is considerable debate whether Alzheimer's disease (AD) originates in basal
forebrain or entorhinal cortex. Here we examined whether longitudinal decreases in basal …

Importance Characterizing longitudinal patterns of regional brain volume changes in a
population with normal cognition at the individual level could improve understanding of the …

The purpose of this study was to use serial imaging to gain insight into the sequence of
pathologic events in Alzheimer's disease, and the clinical features associated with this …

Brain imaging studies have shown that slow and progressive cerebral atrophy characterized
the development of Alzheimer's Disease (AD). Despite a large number of studies dedicated …

Clinicopathological evidence suggests that the pathology of Alzheimer's disease (AD)
begins many years before the appearance of cognitive symptoms. Biomarkers are required …

Imaging studies of cerebral volumes often adjust for factors such as age that may confound
between-subject comparisons. However the use of nuisance covariates in imaging studies is …