Ecology and genomics of Actinobacteria: new concepts for natural product discovery

DA van Bergeijk, BR Terlouw, MH Medema… - Nature Reviews …, 2020 - nature.com
Actinobacteria constitute a highly diverse bacterial phylum with an unrivalled metabolic
versatility. They produce most of the clinically used antibiotics and a plethora of other natural …

Genomics of Actinobacteria: Tracing the Evolutionary History of an Ancient Phylum

M Ventura, C Canchaya, A Tauch… - Microbiology and …, 2007 - Am Soc Microbiol
Actinobacteria constitute one of the largest phyla among Bacteria and represent gram-
positive bacteria with a high G+ C content in their DNA. This bacterial group includes …

Genomic basis for natural product biosynthetic diversity in the actinomycetes

M Nett, H Ikeda, BS Moore - Natural product reports, 2009 - pubs.rsc.org
Covering: up to mid-2009 The phylum Actinobacteria hosts diverse high G+ C, Gram-
positive bacteria that have evolved a complex chemical language of natural product …

The complex extracellular biology of Streptomyces

KF Chater, S Biró, KJ Lee, T Palmer… - FEMS microbiology …, 2010 - academic.oup.com
Streptomycetes, soil-dwelling mycelial bacteria that form sporulating aerial branches, have
an exceptionally large number of predicted secreted proteins, including many exported via …

Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism

M Komatsu, T Uchiyama, S Ōmura… - Proceedings of the …, 2010 - National Acad Sciences
To construct a versatile model host for heterologous expression of genes encoding
secondary metabolite biosynthesis, the genome of the industrial microorganism …

Genome Sequence of the Streptomycin-Producing Microorganism Streptomyces griseus IFO 13350

Y Ohnishi, J Ishikawa, H Hara, H Suzuki… - Journal of …, 2008 - Am Soc Microbiol
We determined the complete genome sequence of Streptomyces griseus IFO 13350, a soil
bacterium producing an antituberculosis agent, streptomycin, which is the first …

Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens

L Laureti, L Song, S Huang, C Corre… - Proceedings of the …, 2011 - National Acad Sciences
There is a constant need for new and improved drugs to combat infectious diseases, cancer,
and other major life-threatening conditions. The recent development of genomics-guided …

Genome sequencing reveals complex secondary metabolome in the marine actinomycete Salinispora tropica

DW Udwary, L Zeigler, RN Asolkar… - Proceedings of the …, 2007 - National Acad Sciences
Recent fermentation studies have identified actinomycetes of the marine-dwelling genus
Salinispora as prolific natural product producers. To further evaluate their biosynthetic …

Streptomyces

P Kämpfer - Bergey's manual of systematics of archaea and …, 2015 - Wiley Online Library
Strep. to. my'ces. Gr. adj. streptos pliant, bent; Gr. masc. n. mukês fungus; NL masc. n.
Streptomyces pliant or bent fungus. Actinobacteria/Actinobacteria/Streptomycetales …

Genetic manipulation of secondary metabolite biosynthesis for improved production in Streptomyces and other actinomycetes

RH Baltz - Journal of Industrial Microbiology and Biotechnology, 2016 - academic.oup.com
Actinomycetes continue to be important sources for the discovery of secondary metabolites
for applications in human medicine, animal health, and crop protection. With the maturation …