Anagen stage hair follicles (HFs) exhibit “immune privilege (IP)” from the level of the bulge
downwards to the bulb. Both passive and active IP mechanisms protect HFs from …

Nearly 50 years ago, Chase published a review of hair cycling in which he detailed hair
growth in the mouse and integrated hair biology with the biology of his day. In this review we …

The classical observations of the skin as a target for melanotropins have been
complemented by the discovery of their actual production at the local level. In fact, all of the …

This review focuses on the role of the peripheral nervous system in cutaneous biology and
disease. During the last few years, a modern concept of an interactive network between …

The skin is a known target organ for the proopiomelanocortin (POMC)-derived
neuropeptides α-melanocyte stimulating hormone (α-MSH), β-endorphin, and ACTH and …

The skin and its major appendages are prominent target organs and potent sources of key
players along the classical hypothalamic‐pituitary axis, such as corticotropin releasing …

The hair follicle, a unique characteristic of mammals, represents a stem cell‐rich, prototypic
neuroectodermal‐mesodermal interaction system. This factory for pigmented epithelial fibers …

Recent findings have shed new light on the role of peripheral nerves in the skin and
established a modern concept of cutaneous neurobiology. Closely related monodirectional …

This essay reviews the available evidence that the proximal hair follicle epithelium
generates and maintains an area of relative immune privilege during a defined segment of …

Tumour architecture mimics many of the features of normal tissues, with a cellular hierarchy
that regulates the balance between cell renewal and cell death. Although many tumours …