TMBserval: a statistical explainable learning model reveals weighted tumor mutation burden better categorizing therapeutic benefits
A high tumor mutation burden (TMB) is known to drive the response to immune checkpoint
inhibitors (ICI) and is associated with favorable prognoses. However, because it is a one …
inhibitors (ICI) and is associated with favorable prognoses. However, because it is a one …
What makes TMB an ambivalent biomarker for immunotherapy? A subtle mismatch between the sample-based design of variant callers and real clinical cohort
Y Liu, S Wang, Y Wang, Y Li, X Zhu, X Lai… - Frontiers in …, 2023 - frontiersin.org
Tumor mutation burden (TMB) is a widely recognized biomarker for predicting the efficacy of
immunotherapy. However, its use still remains highly controversial. In this study, we examine …
immunotherapy. However, its use still remains highly controversial. In this study, we examine …
TMBstable: a variant caller controls performance variation across heterogeneous sequencing samples
S Wang, X Zhu, X Wang, Y Liu, M Zhao… - Briefings in …, 2024 - academic.oup.com
In cancer genomics, variant calling has advanced, but traditional mean accuracy evaluations
are inadequate for biomarkers like tumor mutation burden, which vary significantly across …
are inadequate for biomarkers like tumor mutation burden, which vary significantly across …
DeepLION2: deep multi-instance contrastive learning framework enhancing the prediction of cancer-associated T cell receptors by attention strategy on motifs
X Qian, G Yang, F Li, X Zhang, X Zhu, X Lai… - Frontiers in …, 2024 - frontiersin.org
Introduction T cell receptor (TCR) repertoires provide valuable insights into complex human
diseases, including cancers. Recent advancements in immune sequencing technology have …
diseases, including cancers. Recent advancements in immune sequencing technology have …
Development of a risk assessment model for cardiac injury in patients newly diagnosed with acute myeloid leukemia based on a multicenter, real-world analysis in …
L Ma, Q Wang, X Li, Y Shang, N Zhang, J Wu, Y Liang… - BMC cancer, 2024 - Springer
Background Studies have revealed that acute myeloid leukemia (AML) patients are prone to
combined cardiac injury. We aimed to identify hematological risk factors associated with …
combined cardiac injury. We aimed to identify hematological risk factors associated with …
CYP19A1 promotes gastric cancer as part of a lipid metabolism-related gene signature related to the response of immunotherapy and prognosis
X Zhou, F Meng, L Xiao, H Shen - BMC Medical Genomics, 2023 - Springer
Background Increasing evidence suggests that the metabolism of lipids plays a crucial role
in the progression of gastric cancer. However, the expression of lipid metabolism-related …
in the progression of gastric cancer. However, the expression of lipid metabolism-related …
Molecular subtype identification and prognosis stratification based on golgi apparatus-related genes in head and neck squamous cell carcinoma
A Zhang, X He, C Zhang, X Tang - BMC Medical Genomics, 2024 - Springer
Background Abnormal dynamics of the Golgi apparatus reshape the tumor
microenvironment and immune landscape, playing a crucial role in the prognosis and …
microenvironment and immune landscape, playing a crucial role in the prognosis and …
A Statistical Explainable Learning Model Optimizing Co-localization of Multidimensional Positivity Thresholds in Immunotherapy Decision-Supporting
Y Wang, J Liu, J Zhao, J Wang… - … on Bioinformatics and …, 2023 - ieeexplore.ieee.org
Tumor Mutation Burden (TMB) serves as a recognized stratified biomarker for
immunotherapy. However, its one-dimensional representation of non-synonymous genetic …
immunotherapy. However, its one-dimensional representation of non-synonymous genetic …
SPAJoint: A Multivariate Saddlepoint Approximation for Time-to-Event and Response Joint Analysis
X Lai, M An, X Zhang, X Zhu, Y Liu, Y Shao, J Wang… - 2024 - researchsquare.com
Time-to-event and response endpoints are typical phenotypes in association studies that
often exhibit stochastic correlation within the same individual. However, current analytic …
often exhibit stochastic correlation within the same individual. However, current analytic …
DOES GEN Z CONSUMERS REWARD TRADEMARK INFRINGEMENT IN THE COSMETIC INDUSTRY: A PLS-SEM ANALYSIS OF BRAND PATRONAGE IN AFRICA …
TA ABDULSALAM, RB TAJUDEEN… - GUSAU JOURNAL OF …, 2023 - gujeds.com.ng
The cosmetics industry's remarkable growth, driven by consumers' increasing focus on self-
care and wellness, reflects a compound annual growth rate of 8.84%, with revenues …
care and wellness, reflects a compound annual growth rate of 8.84%, with revenues …