The homochirality of biomolecules in nature, such as DNA, RNA, peptides and proteins, has
played a critical role in establishing and sustaining life on Earth. This chiral bias has also …

Total chemical protein synthesis provides access to entire D‐protein enantiomers enabling
unique applications in molecular biology, structural biology, and bioactive compound …

Widespread adoption of mirror-image biological systems presents difficulties in accessing
the requisite D-protein substrates. In particular, mirror-image phage display has the potential …

D‐peptide ligands can be screened for therapeutic potency and enzymatic stability using
synthetic mirror‐image proteins (D‐proteins), but efficient acquisition of these D‐proteins …

The development of mirror-image biology systems and related applications is hindered by
the lack of effective methods to sequence mirror-image (D-) proteins. Although natural …

Immunogenic responses by protein therapeutics often lead to reduced therapeutic effects
and/or adverse effects via the generation of neutralizing antibodies and/or antidrug …

Mirror-image proteins and peptides composed of D-amino acids are garnering increasing
attention as diagnostic agents and drug candidates due to their higher stability and lower …

Mirror-image proteins (d-proteins) are promising scaffolds for drug discovery because of
their high proteolytic stability and low immunogenic properties. Facile and reproducible …

Immunogenicity is a major caveat of protein therapeutics. In particular, the long-term
administration of protein therapeutic agents leads to the generation of antidrug antibodies …

The tumor vasculature plays a crucial role in promoting tumor growth and metastasis,
showcasing heterogeneity in terms of tissue composition, functionality, and structural …