The RET gene encodes a receptor tyrosine kinase that is expressed in neural crest-derived
cell lineages. The RET receptor plays a crucial role in regulating cell proliferation, migration …

Six multiple endocrine neoplasia (MEN) syndromes have received a level of attention that
might seem disproportionate to their low prevalence. The attention has been given because …

This volume covers tumors of the pituary, the thyroid and parathyroid, the adrenal gland, the
endocrine pancreas, and inherited tumor syndromes. Each entity is extensively discussed …

Background An age-related progression from C-cell hyperplasia to medullary thyroid
carcinoma is associated with various germ-line mutations in the rearranged during …

Tumor heterogeneity is a confusing finding in the assessment of neoplasms, potentially
resulting in inaccurate diagnostic, prognostic and predictive tests. This tumor heterogeneity …

The worldwide incidence of thyroid malignancies has been increasing rapidly. Sensitive
imaging modalities and early detection of thyroid lesions have made thyroid cancers the …

Familial medullary thyroid carcinoma is related to germ-line mutations in the RET oncogene,
mainly in cysteine codon 10 or 11, whereas noncysteine mutations in codons 13–15 are …

OBJECTIVE. This article will review the multimodality imaging spectrum of medullary thyroid
carcinoma (MTC) with an emphasis on anatomic and functional imaging. Recent advances …

Background: Diffuse proliferation of interstitial cells of Cajal (ICCs) in the myenteric plexus
layer of the intestine has been described in patients with familial and multiple …

The successful use of high-dose synthetic estrogens to treat postmenopausal metastatic
breast cancer is the first effective 'chemical therapy'proven in clinical trial to treat any cancer …