Enzymes are an attractive alternative in the asymmetric syntheses of chiral building blocks.
To meet the requirements of industrial biotechnology and to introduce new functionalities …

Biomolecular engineering can be used to purposefully manipulate biomolecules, such as
peptides, proteins, nucleic acids and lipids, within the framework of the relations among their …

Modeling the impact of amino acid mutations on protein-protein interaction plays a crucial
role in protein engineering and drug design. In this study, we develop GeoPPI, a novel …

Biocatalytic carbon‐carbon bond formation by means of aldolases offers an exceptionally
stereoselective and green tool for this strategic reaction in synthetic organic chemistry …

Computer-aided design, pervasive in other engineering disciplines, is currently developing
in synthetic biology. Concepts for standardization and hierarchies of parts, devices and …

The field of bioinformatics and computational biology has gone through a number of
transformations during the past 15 years, establishing itself as a key component of new …

In the past decade, a concerted effort to successfully capture specific tertiary packing
interactions produced specific three-dimensional structures for many de novo designed …

Locating sequences compatible with a protein structural fold is the well‐known inverse
protein‐folding problem. While significant progress has been made, the success rate of …

We have investigated recently reported computationally designed retroaldolase enzymes
with the goal of understanding the extent and the origins of their catalytic power. Direct …

The combination of computational and directed evolution methods has proven a winning
strategy for protein engineering. We refer to this approach as computer-aided protein …