Verification of molecular subtyping of bladder cancer in the GUSTO clinical trial

J Griffin, J Down, LA Quayle, PR Heath… - The Journal of …, 2024 - Wiley Online Library
The GUSTO clinical trial (Gene expression subtypes of Urothelial carcinoma: Stratified
Treatment and Oncological outcomes) uses molecular subtypes to guide neoadjuvant …

Industrialized, artificial intelligence-guided laser microdissection for microscaled proteomic analysis of the tumor microenvironment

D Mitchell, AL Hunt, KA Conrads, BL Hood… - JoVE (Journal of …, 2022 - jove.com
The tumor microenvironment (TME) represents a complex ecosystem comprised of dozens
of distinct cell types, including tumor, stroma, and immune cell populations. To characterize …

Rigorous software pipeline for clinical somatic mutation analyses of solid tumors

I Stoimenov, M Rashyna, T Adlerteg, L Nunes… - medRxiv, 2023 - medrxiv.org
Mutational analyses of tumor DNA guide the use of targeted therapies and checkpoint
inhibitors in management of solid tumors. Reducing false positive mutation calls without …