Potential mechanisms of quercetin in cancer prevention: focus on cellular and molecular targets

P Asgharian, AP Tazekand, K Hosseini… - Cancer cell …, 2022 - Springer
Over the past few years, the cancer-related disease has had a high mortality rate and
incidence worldwide, despite clinical advances in cancer treatment. The drugs used for …

A renewed concept on the MAPK signaling pathway in cancers: Polyphenols as a choice of therapeutics

J Anjum, S Mitra, R Das, R Alam, A Mojumder… - Pharmacological …, 2022 - Elsevier
Abnormalities in the mitogen-activated protein kinase (MAPK) signaling pathway are a key
contributor to the carcinogenesis process and have therefore been implicated in several …

A comprehensive analysis and anti-cancer activities of quercetin in ROS-mediated cancer and cancer stem cells

P Biswas, D Dey, PK Biswas, TI Rahaman… - International journal of …, 2022 - mdpi.com
Reactive oxygen species (ROS) induce carcinogenesis by causing genetic mutations,
activating oncogenes, and increasing oxidative stress, all of which affect cell proliferation …

[HTML][HTML] Quercetin, a natural flavonoid interacts with DNA, arrests cell cycle and causes tumor regression by activating mitochondrial pathway of apoptosis

S Srivastava, RR Somasagara, M Hegde, M Nishana… - Scientific reports, 2016 - nature.com
Naturally occurring compounds are considered as attractive candidates for cancer treatment
and prevention. Quercetin and ellagic acid are naturally occurring flavonoids abundantly …

Quercetin inhibits prostate cancer by attenuating cell survival and inhibiting anti-apoptotic pathways

AB Ward, H Mir, N Kapur, DN Gales… - World journal of surgical …, 2018 - Springer
Background Despite recent advances in diagnosis and treatment, prostate cancer (PCa)
remains the leading cause of cancer-related deaths in men. Current treatments offered in the …

Quercetin in cancer treatment, alone or in combination with conventional therapeutics?

A Filipa Brito, M Ribeiro… - Current medicinal …, 2015 - ingentaconnect.com
Cancer is a problem of global importance, since the incidence is increasing worldwide and
therapeutic options are generally limited. Thus, it becomes imperative to find new …

Polyphenolic phytochemicals in cancer prevention and therapy: bioavailability versus bioefficacy

JM Estrela, S Mena, E Obrador… - Journal of medicinal …, 2017 - ACS Publications
Natural polyphenols are organic chemicals which contain phenol units in their structures.
They show antitumor properties. However, a key problem is their short half-life and low …

Site-specific anticancer effects of dietary flavonoid quercetin

K Sak - Nutrition and cancer, 2014 - Taylor & Francis
Food-derived flavonoid quercetin, widely distributed in onions, apples, and tea, is able to
inhibit growth of various cancer cells indicating that this compound can be considered as a …

Molecular mechanisms of action of quercetin in cancer: recent advances

D Kashyap, S Mittal, K Sak, P Singhal, HS Tuli - Tumor Biology, 2016 - Springer
In the last few decades, the scientific community has discovered an immense potential of
natural compounds in the treatment of dreadful diseases such as cancer. Besides the …

Pharmacological properties of trichostatin A, focusing on the anticancer potential: A comprehensive review

A Bouyahya, N El Omari, M Bakha, T Aanniz… - Pharmaceuticals, 2022 - mdpi.com
Trichostatin A (TSA), a natural derivative of dienohydroxamic acid derived from a fungal
metabolite, exhibits various biological activities. It exerts antidiabetic activity and reverses …