Abstract The Zero Childhood Cancer Program is a precision medicine program to benefit
children with poor-outcome, rare, relapsed or refractory cancer. Using tumor and germline …

Understanding the progression of early human embryonic development prior to implantation
is of fundamental biological importance. Greater insights into early developmental events …

The activation of the embryonic genome marks the first major wave of transcription in the
developing organism. Zygotic genome activation (ZGA) in mouse 2-cell embryos and 8-cell …

To better understand transcriptional regulation during human oogenesis and
preimplantation development, we defined stage-specific transcription, which highlighted the …

In human embryos, the initiation of transcription (embryonic genome activation [EGA]) occurs
by the eight-cell stage, but its exact timing and profile are unclear. To address this, we …

Translational regulation plays a critical role during the oocyte-to-embryo transition (OET)
and zygotic genome activation (ZGA). Here, we integrated ultra-low-input ribosome profiling …

Early pregnancy is a complex and well-orchestrated differentiation process that involves all
the cellular elements of the fetal-maternal interface. Aberrant trophoblast-decidual …

In human embryos, major zygotic genome activation (ZGA) initiates at the eight-cell (8C)
stage. Abnormal ZGA leads to developmental defects and even contributes to the failure of …

CRISPR-Cas9-based gene activation (CRISPRa) is an attractive tool for cellular
reprogramming applications due to its high multiplexing capacity and direct targeting of …

Embryonic genome activation (EGA) is critical for embryonic development. However, our
understanding of the regulatory mechanisms of human EGA is still incomplete. Human …