Big data analytics for genomic medicine
Genomic medicine attempts to build individualized strategies for diagnostic or therapeutic
decision-making by utilizing patients' genomic information. Big Data analytics uncovers …
decision-making by utilizing patients' genomic information. Big Data analytics uncovers …
[HTML][HTML] Next-generation sequencing in drug development: target identification and genetically stratified clinical trials
AD Torshizi, K Wang - Drug discovery today, 2018 - Elsevier
Highlights•Recent applications of next-generation sequencing in drug discovery are
covered.•The first FDA-approved gene therapy for cancer and inherited disease are …
covered.•The first FDA-approved gene therapy for cancer and inherited disease are …
Use of real-world data for the research, development, and evaluation of oncology precision medicines
JRR Lewis, I Kerridge, W Lipworth - JCO precision oncology, 2017 - ascopubs.org
Although randomized controlled trials remain the scientific ideal for determining the efficacy
and safety of new treatments, they are sometimes insufficient to address the evidentiary …
and safety of new treatments, they are sometimes insufficient to address the evidentiary …
Clinical and genetic characteristics of carriers of the TP53 c. 541C> T, p. Arg181Cys pathogenic variant causing hereditary cancer in patients of Arab-Muslim descent
J Arnon, A Zick, M Maoz, N Salaymeh, A Gugenheim… - Familial Cancer, 2024 - Springer
TP53 pathogenic variants cause Li-Fraumeni syndrome (LFS), with some variants causing
an attenuated phenotype. Herein, we describe the clinical phenotype and genetic …
an attenuated phenotype. Herein, we describe the clinical phenotype and genetic …
DNA Mismatch Repair Proteins and BRAF V600E Detection by Immunohistochemistry in Colorectal Cancer Demonstrates Concordance with Next Generation …
J Yambert, LA Henricksen, J Clements… - Journal of Molecular …, 2022 - mdpi.com
Background and Aims: Multiple laboratory methods are used to screen patients with
colorectal cancer (CRC) for mismatch repair (MMR) protein deficiency to identify possible …
colorectal cancer (CRC) for mismatch repair (MMR) protein deficiency to identify possible …
Aprendizagem Automática na Identificação de Variantes Genéticas Associadas ao Cancro do Cólon e do Reto
MMN Lopes - 2023 - search.proquest.com
O Cancro do Cólon e Reto (CCR) é um dos tipos de cancro com maior taxa de incidência e
mortalidade, e onde o número de casos em doentes jovens tem aumentado consideravel …
mortalidade, e onde o número de casos em doentes jovens tem aumentado consideravel …