Osteoarthritis: pathogenic signaling pathways and therapeutic targets
Osteoarthritis (OA) is a chronic degenerative joint disorder that leads to disability and affects
more than 500 million population worldwide. OA was believed to be caused by the wearing …
more than 500 million population worldwide. OA was believed to be caused by the wearing …
MicroRNAs in intervertebral disc degeneration, apoptosis, inflammation, and mechanobiology
P Cazzanelli, K Wuertz-Kozak - International journal of molecular …, 2020 - mdpi.com
Intervertebral disc (IVD) degeneration is a multifactorial pathological process associated
with low back pain, the leading cause of years lived in disability worldwide. Key …
with low back pain, the leading cause of years lived in disability worldwide. Key …
The function of microRNAs in cartilage and osteoarthritis
T Swingler, L Niu, P Smith, P Paddy… - Clinical and …, 2019 - ueaeprints.uea.ac.uk
MicroRNAs are small double-stranded RNAs, which negatively regulate gene expression
and have been shown to have key roles in both chondrocyte development and cartilage …
and have been shown to have key roles in both chondrocyte development and cartilage …
LncRNA MALAT1 promotes osteoarthritis by modulating miR-150-5p/AKT3 axis
Y Zhang, F Wang, G Chen, R He, L Yang - Cell & bioscience, 2019 - Springer
Background Many studies have reported that long noncoding RNAs (lncRNAs) could act as
sponges for microRNAs (miRNAs) and play important roles in the regulation of osteoarthritis …
sponges for microRNAs (miRNAs) and play important roles in the regulation of osteoarthritis …
RNA sequencing data integration reveals an miRNA interactome of osteoarthritis cartilage
Objective To uncover the microRNA (miRNA) interactome of the osteoarthritis (OA)
pathophysiological process in the cartilage. Methods We performed RNA sequencing in 130 …
pathophysiological process in the cartilage. Methods We performed RNA sequencing in 130 …
Interplay between genetics and epigenetics in osteoarthritis
Research into the molecular genetics of osteoarthritis (OA) has been substantially bolstered
in the past few years by the implementation of powerful genome-wide scans that have …
in the past few years by the implementation of powerful genome-wide scans that have …
[HTML][HTML] Senescence cell–associated extracellular vesicles serve as osteoarthritis disease and therapeutic markers
Senescent cells (SnCs) are increasingly recognized as central effector cells in age-related
pathologies. Extracellular vesicles (EVs) are potential cellular communication tools through …
pathologies. Extracellular vesicles (EVs) are potential cellular communication tools through …
Crosstalk among circRNA/lncRNA, miRNA, and mRNA in osteoarthritis
H Kong, ML Sun, XA Zhang, XQ Wang - Frontiers in Cell and …, 2021 - frontiersin.org
Osteoarthritis (OA) is a joint disease that is pervasive in life, and the incidence and mortality
of OA are increasing, causing many adverse effects on people's life. Therefore, it is very vital …
of OA are increasing, causing many adverse effects on people's life. Therefore, it is very vital …
[HTML][HTML] CircCDK14 protects against Osteoarthritis by sponging miR-125a-5p and promoting the expression of Smad2
P Shen, Y Yang, G Liu, W Chen, J Chen, Q Wang… - Theranostics, 2020 - ncbi.nlm.nih.gov
Rationale: Osteoarthritis (OA) is the most common joint disease worldwide. Previous studies
have identified the imbalance between extracellular matrix (ECM) catabolism and anabolism …
have identified the imbalance between extracellular matrix (ECM) catabolism and anabolism …
Biological strategies for osteoarthritis: from early diagnosis to treatment
Purpose To provide an updated review of the literature on the use of orthobiologics as a
potential treatment option to alleviate symptoms associated with osteoarthritis (OA), slow the …
potential treatment option to alleviate symptoms associated with osteoarthritis (OA), slow the …