Systemic immunoglobulin light chain amyloidosis is a protein misfolding disease caused by
the conversion of immunoglobulin light chains from their soluble functional states into highly …

The conversion of native peptides and proteins into amyloid aggregates is a hallmark of over
50 human disorders, including Alzheimer's and Parkinson's diseases. Increasing evidence …

Systemic light chain amyloidosis (AL) is a life-threatening disease caused by aggregation
and deposition of monoclonal immunoglobulin light chains (LC) in target organs. Severity of …

The treatment of patients with systemic light chain (AL) amyloidosis is a challenge to
hematologists. Despite its generally small size, the underlying clone causes a rapidly …

Systemic amyloidosis is caused by misfolding and extracellular deposition of circulating
proteins as amyloid fibrils, resulting in the dysfunction of vital organs. The most common …

Light chain (AL) amyloidosis is a devastating, complex, and incurable protein misfolding
disease. It is characterized by an abnormal proliferation of plasma cells (fully differentiated B …

Each of the 30 human amyloid diseases is associated with the aggregation of a particular
precursor protein into amyloid fibrils. In transthyretin amyloidosis (ATTR), mutant or wild-type …

AL amyloidosis is characterized by widespread deposition of immunoglobulin light chains
(LCs) as amyloid fibrils. Cardiac involvement is frequent and leads to life-threatening …

In systemic light chain amyloidosis, an overexpressed antibody light chain (LC) forms fibrils
which deposit in organs and cause their failure. While it is well-established that mutations in …

Light chain amyloidosis (AL), the most common systemic amyloidosis, is caused by the
overproduction and the aggregation of monoclonal immunoglobulin light chains (LC) in …