Several decades of basic and clinical research have demonstrated that there is an
association between the insulin-like growth factors (IGFs) and neoplasia. We begin with a …

Soy isoflavones are dietary components for which an association has been demonstrated
with reduced risk of prostate cancer (PCa) in Asian populations. However, the exact …

The type 1 insulin-like growth factor receptor (IGF-1R), a transmembrane tyrosine kinase, is
widely expressed across many cell types in foetal and postnatal tissues. Activation of the …

The type 1 insulin‐like growth factor receptor (IGF‐1R) plays an important role in the
establishment and maintenance of the transformed phenotype. It also has a strong …

Targeted gene mutations have established distinct, yet overlapping, developmental roles for
receptors of the insulin/IGF family. IGF-I receptor mediates IGF-I and IGF-II action on prenatal …

The type 1 insulin-like growth factor receptor (IGF-1R), activated by its ligands, protects
several cell types from a variety of apoptotic injuries. The main signaling pathway for IGF-1R …

The insulin receptor substrate-1 (IRS-1), a docking protein for both the type 1 insulin-like
growth factor receptor (IGF-IR) and the insulin receptor, is known to send a mitogenic, anti …

The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently
overexpressed by tumours, and mediates proliferation and apoptosis protection. IGF …

The type 1 insulin-like growth factor receptor (IGF-IR) sends several signals, some of which
are contradictory. When the concentrations of insulin receptor substrate 1 (IRS-1), a major …

The type 1 insulin-like growth factor receptor (IGF-IR) plays an important role in both normal
and abnormal growth. It is particularly important in anchorage-independent growth …