Genomic technologies have led to massive gains in our understanding of human gene
function and disease relevance. Chemical biologists are a primary beneficiary of this …

DNA-encoded chemical libraries (DELs) consist of large chemical compound collections
individually linked to DNA barcodes, facilitating pooled construction and screening …

H8–BINOL, a partially reduced form of BINOL, is widely employed in a broad array of
organocatalyzed asymmetric methodologies. Over the last 25 years, asymmetric …

The fraction of sp3-hybridized carbons (F sp3) and the fraction of stereogenic carbons (F
Cstereo) are two widely employed scores of molecular complexity with strong links to …

We achieved a concise total synthesis of salimabromide by using a novel intramolecular
radical cyclization to simultaneously construct the unique benzo-fused [4.3. 1] carbon …

Monoterpene indole alkaloids (MIAs) are endowed with high structural and spatial
complexity and characterized by diverse biological activities. Given this complexity‐activity …

Chiral natural compounds are often biosynthesized in an enantiomerically pure fashion, and
stereochemistry plays a pivotal role in biological activity. Herein, we investigated the …

Molecular complexity (MC) lacks a universal definition, but various studies address it in
contexts ranging from ligand–receptor interactions to DNA sequencing, with the overarching …

Chemical probes are invaluable tools to investigate biological processes and can serve as
lead molecules for the development of new therapies. However, despite their utility, only a …

Chirality recognition of pharmaceutical products plays a significant part in asymmetric
synthesis, stereoselective catalysis, supramolecular chemistry, and the development of new …