Phosphoinositide-specific phospholipase C is an effector molecule in the signal transduction
process. It generates two second messengers, inositol-1, 4, 5-trisphosphate and …

Over the past 15 years or so, numerous studies have sought to characterise how nuclear
calcium (Ca2+) signals are generated and reversed, and to understand how events that …

Neurotrophins constitute a family of growth factors initially characterized as predominant
mediators of nervous system development, neuronal survival, regeneration and plasticity …

Background Cerebral palsy (CP) is an upper motor neuron disease that results in a
progressive movement disorder. Secondary to the neurological insult, muscles from CP …

Specific nuclear sub-compartments that are regions of fundamental processes such as gene
expression or DNA repair, contain phosphoinositides (PIPs). PIPs thus potentially represent …

Protein kinases C (PKCs) are a family of serine/threonine kinases which act as key
regulators in cell cycle progression and differentiation. Studies of the involvement of PKCs in …

Abstract Phosphoinositide-phospholipase C-β1 (PLC-β1) plays a crucial role in the initiation
of the genetic program responsible for muscle differentiation and osteogenesis. During …

Here, we provide evidence for the presence of Myosin phosphatase rho-interacting protein
(MPRIP), an F-actin-binding protein, in the cell nucleus. The MPRIP protein binds to …

Ca2+ signalling is important for controlling gene transcription. Changes of the cytosolic
Ca2+ ([Ca2+] C) may promote migration of transcription factors or transcriptional regulators …

Mammalian muscle development is regulated by complex gene networks at the molecular
level. The revelation of gene regulatory mechanisms is an important basis for the study of …