Antimicrobial resistance has become a significant public health problem globally with
multidrug resistant Gram negative (MDR-GN) bacteria being the main representatives. The …

Colistin and other polymyxin antibiotics have become increasingly used in clinical settings
as a result of treating multidrug-resistant infections in critically ill patients. The highly variable …

Neonatal sepsis is a leading cause of morbidity and mortality in neonates, particularly in low-
and middle-income countries. The emergence of antimicrobial resistance is a rapidly …

Background Current polymyxin B dosing in children relies on scant data. Objectives To build
a population pharmacokinetic (PK) model for polymyxin B in paediatric patients and assess …

Antimicrobial resistance is an increasing public health threat across the globe for neonates,
infants and children. 1 The burden of antibiotic-resistant infections in neonates and children …

This document provides interim recommendations for appropriate colistin use (polymyxin E)
to treat bacterial infections in neonates, infants, and children. Colistin, a polymyxin antibiotic …

Antibiotic-resistant Gram-negative bacteria can cause severe infections in children
especially in hemato-oncology, transplant (solid organ or hematopoietic stem cells) …

Objectives The aim of this study was to describe the population pharmacokinetics of
intravenous colistin use in children and to propose optimal dosage regimens. Methods A …

Background: This study aimed to investigate the efficacy and safety of intravenous colistin in
pediatric patients with nosocomial Gram-negative bacteria infections and to determine …

CONSENSUS GUIDELINES ON TREATMENT OF MULTIDRUG RESISTANT GRAM NEGATIVES
Page 1 CONSENSUS GUIDELINES ON TREATMENT OF MULTIDRUG RESISTANT GRAM …