Targeting the holy triangle of quorum sensing, biofilm formation, and antibiotic resistance in pathogenic bacteria

RV Sionov, D Steinberg - Microorganisms, 2022 - mdpi.com
Chronic and recurrent bacterial infections are frequently associated with the formation of
biofilms on biotic or abiotic materials that are composed of mono-or multi-species cultures of …

Revisiting the virulence hallmarks of Pseudomonas aeruginosa: a chronicle through the perspective of quorum sensing

J Chadha, K Harjai, S Chhibber - Environmental microbiology, 2022 - Wiley Online Library
Pseudomonas aeruginosa is an opportunistic pathogen and the leading cause of mortality
among immunocompromised patients in clinical setups. The hallmarks of virulence in P …

Repurposing phytochemicals as anti‐virulent agents to attenuate quorum sensing‐regulated virulence factors and biofilm formation in Pseudomonas aeruginosa

J Chadha, K Harjai, S Chhibber - Microbial biotechnology, 2022 - Wiley Online Library
Unregulated consumption and overexploitation of antibiotics have paved the way for
emergence of antibiotic‐resistant strains and 'superbugs'. Pseudomonas aeruginosa is …

Computational screening of natural compounds as putative quorum sensing inhibitors targeting drug resistance bacteria: Molecular docking and molecular dynamics …

K Chaieb, B Kouidhi, SB Hosawi… - Computers in Biology …, 2022 - Elsevier
Quorum sensing (QS) is a bacterial communication strategy controlling cells density, biofilm
formation, virulence, sporulation, and survival. Since QS is considered a virulence factor in …

Multifaceted strategies for alleviating Pseudomonas aeruginosa infection by targeting protease activity: Natural and synthetic molecules

F Khan - International Journal of Biological Macromolecules, 2024 - Elsevier
Pseudomonas aeruginosa has become a top-priority pathogen in the health sector because
it is ubiquitous, has high metabolic/genetic versatility, and is identified as an opportunistic …

Design and synthesis of novel benzimidazole derivatives as potential Pseudomonas aeruginosa anti-biofilm agents inhibiting LasR: Evidence from comprehensive …

RH Abd El-Aleam, AM Sayed, MN Taha… - European Journal of …, 2022 - Elsevier
Quorum sensing (QS) inhibition is one of the potential methods to target bacterial infection.
In this study, comprehensive molecular dynamics simulation (MDS) experiments were …

Sesamin and sesamolin rescues Caenorhabditis elegans from Pseudomonas aeruginosa infection through the attenuation of quorum sensing regulated virulence …

VT Anju, S Busi, S Ranganathan, DR Ampasala… - Microbial …, 2021 - Elsevier
Pseudomonas aeruginosa is an opportunistic pathogen emerging as a public health threat
owing to their multidrug resistance profiles. The quorum sensing systems of P. aeruginosa …

Quorum sensing: a new prospect for the management of antimicrobial-resistant infectious diseases

M Haque, S Islam, MA Sheikh, S Dhingra… - Expert review of anti …, 2021 - Taylor & Francis
Introduction Quorum-sensing (QS) is a microbial cell-to-cell communication system that
utilizes small signaling molecules to mediates interactions between cross-kingdom …

Critical review on plant-derived quorum sensing signaling inhibitors in pseudomonas aeruginosa

K Vadakkan, K Sathishkumar, VO Mapranathukaran… - Bioorganic …, 2024 - Elsevier
Pseudomonas aeruginosa, a biofilm-forming organism with complex quorum mechanisms
(Las, Rhl, PQS, and IQS), poses an imminent danger to the healthcare sector and renders …

Olive Leaf Extract Modulates Quorum Sensing Genes and Biofilm Formation in Multi-Drug Resistant Pseudomonas aeruginosa

NR El-Sayed, R Samir, L Jamil M. Abdel-Hafez… - Antibiotics, 2020 - mdpi.com
Biofilm acts as a complex barrier against antibiotics. In this study, we investigated the
inhibitory activities of Olea europaea (olive) leaves Camellia sinensis (green tea), Styrax …