Interaction in vitro between cells infected with human immunodeficiency virus (HIV) and
surrounding, uninfected, target cells often leads to cell fusion and the formation of …

Hepatitis C virus (HCV) infection is believed to begin with interactions between cell-free
HCV and cell receptors that include CD81, scavenger receptor B1 (SR-B1), claudin-1 …

The neuroregulatory activities of PMS-601, a platelet activating factor antagonist, were
investigated in laboratory and animal models of HIV-1 encephalitis (HIVE). For the former …

The monoclonal antibody 2F5 (mAb 2F5), one of the most potent broadly neutralizing mAbs
targeted to the HIV-1 gp41 membrane proximal exterior region (MPER), displays an …

HIV-1 envelope glycoprotein (Env) is a major determinant of viral pathogenicity. The
evaluation of the biological properties of patient-derived envelopes by comparing two …

Many viruses have the ability to cause cells to fuse into large multi-nucleated cells, known as
syncytia. While the existence of syncytia has long been known and its importance in helping …

Most enveloped viruses fuse with host cells and catalyze fusion among host cells by
expression of specific patterns of N-glycosylation on their envelope proteins. In the 1970s, it …

Cell–cell fusion is a frequent event in nature leading to modification of cell fate. In this
chapter, we describe a flow cytometric procedure for the quantitative assessment of in vitro …

The event of cell-cell fusion is involved in a variety of physiological, but importantly also of
pathophysiological processes. As a prominent example, the formation of skeletal muscle …

In human HIV infection, multinucleated cells (syncytia) are formed by fusion of HIV-infected
cells with CD4+ cells. In order to examine possible functional implications of syncytia …