[HTML][HTML] Voluntary running attenuates behavioural signs of low back pain: dimorphic regulation of intervertebral disc inflammation in male and female SPARC-null …
S Lee, SH Jang, M Suzuki-Narita, S Gregoire… - Osteoarthritis and …, 2022 - Elsevier
OBJECTIVE To examine the effect of running exercise on behavioral measures of pain and
intervertebral disc (IVD) inflammation in the SPARC-null mouse model. METHODS Male and …
intervertebral disc (IVD) inflammation in the SPARC-null mouse model. METHODS Male and …
[HTML][HTML] Exercise attenuates low back pain and alters epigenetic regulation in intervertebral discs in a mouse model
Y Kawarai, SH Jang, S Lee, M Millecamps, HM Kang… - The Spine Journal, 2021 - Elsevier
BACKGROUND CONTEXT Chronic low back pain (LBP) is a multifactorial disorder with
complex underlying mechanisms, including associations with intervertebral disc (IVD) …
complex underlying mechanisms, including associations with intervertebral disc (IVD) …
[HTML][HTML] Engineered extracellular vesicle-based gene therapy for the treatment of discogenic back pain
SN Tang, AI Salazar-Puerta, MK Heimann… - Biomaterials, 2024 - Elsevier
Painful musculoskeletal disorders such as intervertebral disc (IVD) degeneration associated
with chronic low back pain (termed “Discogenic back pain”, DBP), are a significant socio …
with chronic low back pain (termed “Discogenic back pain”, DBP), are a significant socio …
Exercise improves load bearing bone structural properties in female secreted protein acidic and rich in cysteine (SPARC) null mice but not in males
G Kaneda, D Huang, N Pham… - Journal of …, 2024 - Wiley Online Library
Secreted protein acidic and rich in cysteine (SPARC) is the most abundant glycoprotein in
bone and is thought to play a critical role in bone remodeling and homeostasis. However …
bone and is thought to play a critical role in bone remodeling and homeostasis. However …
Senolytic Treatment for Low Back Pain
M Mannarino, H Cherif, S Ghazizadeh, OW Martinez… - bioRxiv, 2024 - biorxiv.org
Senescent cells (SnCs) accumulate due to aging and external cellular stress throughout the
body. They adopt a senescence-associated secretory phenotype (SASP) and release …
body. They adopt a senescence-associated secretory phenotype (SASP) and release …