Kallikrein-related peptidases in prostate, breast, and ovarian cancers: from pathobiology to clinical relevance

M Avgeris, K Mavridis, A Scorilas - Biological chemistry, 2012 - degruyter.com
Tissue kallikrein (KLK1) and kallikrein-related peptidases (KLK2–15) comprise a family of 15
highly conserved secreted serine proteases with similar structural characteristics and a wide …

Kallikrein-related peptidases (KLKs): a gene family of novel cancer biomarkers

CK Kontos, A Scorilas - Clinical Chemistry and Laboratory Medicine …, 2012 - degruyter.com
Early diagnosis of cancer and early detection of relapse following surgery are critical for the
effective treatment of the disease and for a positive clinical outcome. Identification of novel …

Mass spectrometry-based biomarkers to detect prostate cancer: a multicentric study based on non-invasive urine collection without prior digital rectal examination

M Frantzi, Z Culig, I Heidegger, M Mokou, A Latosinska… - Cancers, 2023 - mdpi.com
Simple Summary Prostate cancer is the most frequent cancer type and one of the leading
causes of death in men globally. Multiple biomarkers analyzed in urine have been proposed …

[HTML][HTML] A novel flavonoid composition targets androgen receptor signaling and inhibits prostate cancer growth in preclinical models

K Mamouni, S Zhang, X Li, Y Chen, Y Yang, J Kim… - Neoplasia, 2018 - Elsevier
The high prevalence and long latency period of prostate cancer (PCa) provide a unique
opportunity to control disease progression with dietary and nutraceutical approaches. We …

Cleavage activation of human-adapted influenza virus subtypes by kallikrein-related peptidases 5 and 12

BS Hamilton, GR Whittaker - Journal of Biological Chemistry, 2013 - ASBMB
A critical step in the influenza virus replication cycle is the cleavage activation of the HA
precursor. Cleavage activation of influenza HA enables fusion with the host endosome …

Prognostic value and biological role of the kallikrein-related peptidases in human malignancies

K Mavridis, A Scorilas - Future Oncology, 2010 - Taylor & Francis
Cancer is a substantial health problem for the populations of the Western world. The
discovery of new molecular biomarkers for diagnosis, prognosis and monitoring patients' …

mRNA overexpression of kallikrein-related peptidase 14 (KLK14) is an independent predictor of poor overall survival in chronic lymphocytic leukemia patients

CK Kontos, PG Adamopoulos… - Clinical Chemistry and …, 2016 - degruyter.com
Background: Tissue kallikrein and kallikrein-related peptidases (KLKs) compose a family of
serine endopeptidases with much clinical interest in oncology, as their potential as …

Kallikrein‐related peptidase 4 gene (KLK4) in prostate tumors: Quantitative expression analysis and evaluation of its clinical significance

M Avgeris, K Stravodimos, A Scorilas - The Prostate, 2011 - Wiley Online Library
BACKGROUND Recently accumulating evidences underline the central role of the kallikrein‐
related peptidases family (KLKs) in prostate cancer (PCa) development and progression …

Polyclonal antibodies against kallikrein-related peptidase 4 (KLK4): immunohistochemical assessment of KLK4 expression in healthy tissues and prostate cancer

L Seiz, M Kotzsch, NI Grebenchtchikov… - 2010 - degruyter.com
KLK4 is a member of the human kallikrein-related peptidase family of (chymo) trypsin-like
serine proteases. The aim of the present study was to generate polyclonal antibodies (pAb) …

Expression analysis of osteopontin mRNA splice variants in prostate cancer and benign prostatic hyperplasia

TM Tilli, LC Thuler, AR Matos… - … and molecular pathology, 2012 - Elsevier
Osteopontin splicing isoforms (OPN-SI) present differential expression patterns and specific
tumor roles. Our aims were to characterize OPN-SI expression in prostate cancer (PCa) and …