Wound healing disorders are a societal, clinical, and healthcare burden and understanding
and treating them is a major challenge. A particularly important cell type in the wound …

Epithelial and endothelial cells possess the inherent plasticity to undergo morphological,
cellular, and molecular changes leading to their resemblance of mesenchymal cells. A …

Spiny mice (Acomys cahirinus) are terrestrial mammals that evolved unique scar-free
regenerative wound-healing properties. Myofibroblasts (MFs) are the major scar-forming cell …

Patterned morphologies, such as segments, spirals, stripes, and spots, frequently emerge
during embryogenesis through self-organized coordination between cells. Yet, complex …

From a physical perspective, morphogenesis of tissues results from interplay between their
material properties and the mechanical forces exerted on them. The importance of …

Tissue patterning is critical for the development and regeneration of organs. To advance the
use of engineered reconstituted skin organs, we study cardinal features important for tissue …

The regeneration of hair follicles lost from injury or disease represents a major challenge in
cutaneous regenerative medicine. In this study, we investigated the synergetic effects …

Background Burn injuries can be associated with prolonged healing, infection, a substantial
inflammatory response, extensive scarring, and eventually death. In recent decades, both …

Mammals rapidly heal wounds through fibrous connective tissue build up and tissue
contraction. Recent findings from mouse attribute wound healing to physical mobilization of …

Developing organs are shaped, in part, by physical interaction with their environment in the
embryo. In recent years, technical advances in live-cell imaging and material science have …