Through epigenetic modifications, specific long-term phenotypic consequences can arise
from environmental influence on slowly evolving genomic DNA. Heritable epigenetic …

Our genetic information is tightly packaged into a rather ingenious nucleoprotein complex
called chromatin in a manner that enables it to be rapidly accessed during genomic …

ATP-dependent chromatin remodeling activities function to manipulate chromatin structure
during gene regulation. One of the ways in which they do this is by altering the positions of …

Summary The Chinese herb Dichroa febrifuga has traditionally treated malaria-associated
fever. Its active component febrifugine (FF) and derivatives such as halofuginone (HF) are …

Humans have lived in tenuous battle with malaria over millennia. Today, while much of the
world is free of the disease, areas of South America, Asia, and Africa still wage this war with …

Highlights•Malaria remains a killer disease and drug resistance poses a growing
problem.•Aminoacyl tRNA synthetases (aaRSs) are essential housekeeping …

Histone chaperones physically interact with histones to direct proper assembly and
disassembly of nucleosomes regulating diverse nuclear processes such as DNA replication …

Malaria parasites inevitably develop drug resistance to anti-malarials over time. Hence the
immediacy for discovering new chemical scaffolds to include in combination malaria drug …

Nucleosome assembly proteins (NAPs) are histone chaperones that play a central role in
facilitating chromatin assembly/disassembly which is of fundamental importance for DNA …

The Plasmodium falciparum protein translation enzymes aminoacyl-tRNA synthetases
(aaRSs) are an emergent family of drug targets. The aaRS ensemble catalyses transfer of …