Autophagy is a core molecular pathway for the preservation of cellular and organismal
homeostasis. Pharmacological and genetic interventions impairing autophagy responses …

Autophagy is a conserved lysosomal pathway for the degradation of cytoplasmic
components. Basal autophagy in kidney cells is essential for the maintenance of kidney …

Sodium/glucose cotransporter 2 (SGLT2) inhibitors exert important renoprotective effects in
the diabetic kidney, which cannot be readily explained by their actions to lower blood …

Prompted by the observation that atherosclerotic plaques from human diabetic subjects
displayed lower amounts of NADPH (nicotinamide adenine dinucleotide phosphate) …

Autophagy is a highly conserved process that degrades certain intracellular contents in both
physiological and pathological conditions. Autophagy-related proteins (ATG) are key players …

Albuminuria is the hallmark of both primary and secondary proteinuric glomerulopathies,
including focal segmental glomerulosclerosis (FSGS), obesity-related nephropathy, and …

Diabetic kidney disease, a leading cause of end-stage renal disease, has become a serious
public health problem worldwide and lacks effective therapies. Autophagy is a highly …

Background: Podocyte injury has a direct causal relationship with proteinuria and
glomerulosclerosis and, on a chronic level, can lead to irreversible disease progression …

Background: Diabetic nephropathy (DN) is a serious complication of diabetes mellitus and a
common cause of end-stage renal disease. Autophagy has a defensive role against kidney …

Inhibition of vascular endothelial growth factor A (VEGFA)/vascular endothelial growth factor
receptor 2 (VEGFR2) signaling is a common therapeutic strategy in oncology, with new …