Natural coumarin derivatives activating Nrf2 signaling pathway as lead compounds for the design and synthesis of intestinal anti-inflammatory drugs

LC Di Stasi - Pharmaceuticals, 2023 - mdpi.com
Nrf2 (nuclear factor erythroid 2-related factor 2) is a transcription factor related to stress
response and cellular homeostasis that plays a key role in maintaining the redox system …

Boron compounds exhibit protective effects against aluminum-induced neurotoxicity and genotoxicity: In vitro and in vivo study

H Turkez, S Yıldırım, E Sahin, ME Arslan, B Emsen… - Toxics, 2022 - mdpi.com
Genetic, neuropathological and biochemical investigations have revealed meaningful
relationships between aluminum (Al) exposure and neurotoxic and hematotoxic damage …

Artemisia scoparia and Metabolic Health: Untapped Potential of an Ancient Remedy for Modern Use

A Boudreau, AJ Richard, I Harvey… - Frontiers in …, 2022 - frontiersin.org
Botanicals have a long history of medicinal use for a multitude of ailments, and many
modern pharmaceuticals were originally isolated from plants or derived from …

Protective effects of esculetin against ovary ischemia–reperfusion injury model in rats

M Güvenç, M Yüksel, T Kutlu, M Etyemez… - … of Biochemical and …, 2024 - Wiley Online Library
Aims Ovarian ischemia–reperfusion (I/R) injury is a phenomenon that necessitates urgent
intervention, which occurs as a result of ovarian torsion, and it is frequently seen in young …

Repro-protective activity of amygdalin and spirulina platensis in niosomes and conventional forms against aluminum chloride–induced testicular challenge in adult …

FI Abo El-Ela, A Gamal, HA El-Banna… - Naunyn-schmiedeberg's …, 2024 - Springer
The male reproductive system is negatively influenced by Al exposure. Al represented a
considerable hazard to men's reproduction capabilities. Amygdalin (AMG) and spirulina …

Transcriptome-based analysis of the toxic effects of aluminum chloride exposure on spermatocytes

P Huixin, W Guangji, H Yanxin, P Yanfang, Y Huixiong… - Toxicology in Vitro, 2023 - Elsevier
Aluminum chloride (AlCl 3) exposure is pervasive in our daily lives. Numerous studies have
demonstrated that exposure to AlCl 3 can lead to male reproductive toxicity. However, the …

Carvacrol showed a curative effect on reproductive toxicity caused by Bisphenol AF via antioxidant, anti-inflammatory and anti-apoptotic properties

A Uyar, M Cellat, Ö Kanat, M Etyemez, T Kutlu… - Reproductive …, 2023 - Elsevier
Bisphenol AF (BPAF) is an endocrine disruptor, and human exposure to these chemicals is
growing in industrialized nations. BPAF has been demonstrated in studies to have toxic …

The effect of tyrosol on diclofenac sodium‐induced acute nephrotoxicity in rats

M Çömez, M Cellat, M Kuzu, A Uyar… - … of Biochemical and …, 2024 - Wiley Online Library
Although diclofenac (DCF) is a nonsteroidal anti‐inflammatory drug that is considered safe,
its chronic use and overdose may show some toxic effects. The protective effect of tyrosol …

Human amnion membrane-derived mesenchymal stem cells and conditioned medium can ameliorate X-irradiation-induced testicular injury by reducing endoplasmic …

B Cetinkaya-Un, B Un, M Akpolat, F Andic… - Reproductive …, 2022 - Springer
Today, infertility affects 15% of couples and half of this rate is due to reproductive problems
in men. Radiation-induced damage to the testicles causes sterility depending on the dose …

[HTML][HTML] Aqueous extract of bay leaf (Laurus nobilis) ameliorates testicular toxicity induced by aluminum chloride in rats

AO Falade, KE Adewole, ARO Adekola… - Veterinary …, 2022 - ncbi.nlm.nih.gov
Materials and Methods: Twenty-four Wistar rats were divided into four groups (n= 6, each
group): The control (group 1) received normal saline; Group 2 animals were intraperitoneally …