Ubiquitination plays a pivotal role in several cellular processes and is critical for protein
degradation and signaling. E3 ubiquitin ligases are the matchmakers in the ubiquitination …

The use of natural bioactive constituents from various food sources for anticancer purposes
has become increasingly popular worldwide. Broccoli (Brassica oleracea var. italica) is on …

Cell-to-cell communication strategies include extracellular vesicles (EVs) in plants and
animals. The bioactive molecules in a diet rich in vegetables and fruits are associated with …

A growing amount of evidence indicates that the neuronally expressed developmentally
downregulated 4 (NEDD4, also known as NEDD4-1) E3 ligase plays a critical role in a …

Tumorigenesis, tumor growth, and prognosis are highly related to gene alterations and post-
translational modifications (PTMs). Ubiquitination is a critical PTM that governs practically all …

Owing to several presumed health-promoting biological activities, increased attention is
being given to natural plant chemicals, especially those frequently entering the human diet …

Cancer immunotherapies, including immune checkpoint inhibitors and immune pathway–
targeted therapies, are promising clinical strategies for treating cancer. However, drug …

SARS-CoV-2 is responsible for the ongoing world-wide pandemic which has already taken
more than two million lives. Effective treatments are urgently needed. The enzymatic activity …

A diet rich in cruciferous vegetables such as cauliflower, broccoli, and cabbage has long
been considered healthy, and various epidemiological studies suggest that the consumption …

Introduction: Ubiquitin-proteasome system (UPS) has been validated as a novel anticancer
drug target in the past 20 years. The UPS contains two distinct steps: ubiquitination of a …