There is a need to improve personalized immunosuppression in organ transplantation to
reduce premature graft loss. Biomarkers are needed to better detect rejection, asymptomatic …

The donor-derived cell-free DNA (ddcfDNA) is found in the plasma and urine of kidney
transplant recipients and displays notable potential in diagnosing rejection, specifically …

The invention provides methods for detecting single nucleotide variants in lung cancer,
especially stage 3a lung adenocarcinoma and lung squamous cell carcinoma. Additional …

The present disclosure provides methods for determining the ploidy status of a chromosome
in a gestating fetus from genotypic data measured from a mixed sample of DNA comprising …

The invention provides methods for detecting single nucleotide variants in breast cancer,
bladder cancer, or colorectal cancer. Additional methods and compositions, such as reaction …

In solid organ transplantation, donor-derived cell-free DNA (dd-cfDNA) is a promising
universal noninvasive biomarker for allograft health, where high levels of dd-cfDNA indicate …

Provided herein are methods for determining the ploidy state of one or more chromosome in
a developing fetus. The subject methods provide for increased accuracy by utilizing …

The invention provides methods for simultaneously amplifying multiple nucleic acid regions
of interest in one reaction volume as well as methods for selecting a library of primers for use …

Background. Pancreas transplantation offers patients with diabetes an opportunity for
glucose homeostasis. Current blood tests to surveil for rejection have poor sensitivity and …

The Banff pancreas working schema for diagnosis and grading of rejection is widely used for
treatment guidance and risk stratification in centers that perform pancreas allograft biopsies …