Many tumor cells become resistant to commonly used cytotoxic drugs due to the
overexpression of ATP-binding cassette (ABC) transporters, namely P-glycoprotein (P-gp) …

Phenothiazines belong to the oldest, synthetic antipsychotic drugs, which do not have their
precursor in the world of natural compounds. Apart from their fundamental neuroleptic action …

In this review we focus on the role of the membrane lipids in multidrug resistance and its
modulation. Results of the research performed in recent years indicate the importance of …

It is now well recognized that membrane efflux transporters, especially P-glycoprotein (P-gp;
ABCB1), play a role in determining the absorption, distribution, metabolism, excretion, and …

Generally drugs can act on the level of different biological membranes as well as inside the
cells that are limited by membranes. Even in the latter situation, drugs must still interact with …

Barriere, Reservoir, Wirkort-die Rolle von biologischen Lipidmembranen für die Wirkung von
Medikamenten auf den Organismus ist vielgestaltig. Eine genaue Kenntnis der Eigenarten …

P‐glycoprotein (Pgp), the so‐called multidrug transporter, is a plasma membrane
glycoprotein often involved in the resistance of cancer cells towards multiple anticancer …

This review discusses liposome/water lipophilicity in terms of the structure of liposomes,
experimental methods, and information content. In a first part, the structural properties of the …

Understanding the role of lipids in drug transport is critical in cancer chemotherapy to
overcome drug resistance. In this study, we isolated lipids from doxorubicin-sensitive (MCF …

Multidrug resistance (MDR) is a kind of resistance of cancer cells to multiple classes of
chemotherapic drugs that can be structurally and mechanistically unrelated. Classical MDR …