One of the first biological machineries to be created seems to have been the ribosome.
Since then, organisms have dedicated great efforts to optimize this apparatus. The …

The ribosome is a complex molecular machine composed of numerous distinct proteins and
nucleic acids and is responsible for protein synthesis in every living cell. Ribosome …

Eukaryotic rRNA are modified frequently, although the diversity of modifications is low: in
yeast rRNA, there are only 12 different types out of a possible natural repertoire exceeding …

1.1. Discovery of Sirtuins The founding member of sirtuin is the yeast-silencing information
regulator 2 (SIR2) protein, one of four proteins (SIR1− 4) required for silencing the mating …

Nuclear receptor-binding SET domain-containing 2 (NSD2) is the primary enzyme
responsible for the dimethylation of lysine 36 of histone 3 (H3K36), a mark associated with …

We sought to identify biomarkers which delineated individual hypertrophic responses to
resistance training. Untrained, college-aged males engaged in full-body resistance training …

Synchronization of mitochondrial and cytoplasmic translation rates is critical for the
maintenance of cellular fitness, with cancer cells being especially vulnerable to translational …

Ribosome biogenesis is a complex and highly energy-demanding process that requires the
concerted action of all three nuclear RNA polymerases (Pol I–III) in eukaryotes. The three …

The nucleolus as site of ribosome biogenesis holds a pivotal role in cell metabolism. It is
composed of ribosomal DNA (rDNA), which is present as tandem arrays located in nucleolus …

Anabolism and catabolism are tightly regulated according to the cellular energy supply.
Upon energy stress, ribosomal RNA (rRNA) biogenesis is inhibited, and autophagy is …