Mesenchymal stromal cell extracellular vesicles as therapy for acute and chronic respiratory diseases: A meta‐analysis

A Tieu, K Hu, C Gnyra, J Montroy… - Journal of …, 2021 - Wiley Online Library
Preclinical studies suggest mesenchymal stromal cell extracellular vesicles (MSC‐EVs)
reduce inflammation and improve organ function in lung diseases; however, an objective …

[HTML][HTML] Recent advances in the treatment of complex congenital diaphragmatic hernia—a narrative review

KI Holden, MT Harting - Translational Pediatrics, 2023 - ncbi.nlm.nih.gov
Methods PubMed was searched in late 2022 and early 2023 to identify relevant evidence.
Search terms included congenital diaphragmatic hernia (CDH)”,“extracorporeal life support …

Regenerative medicine: prenatal approaches

P de Coppi, S Loukogeorgakis… - The Lancet Child & …, 2022 - thelancet.com
This two-paper Series focuses on recent advances and applications of regenerative
medicine that could benefit paediatric patients. Innovations in genomic, stem-cell, and tissue …

Puerarin-V prevents the progression of hypoxia-and monocrotaline-induced pulmonary hypertension in rodent models

D Chen, H Zhang, T Yuan, S Sun, R Wang… - Acta Pharmacologica …, 2022 - nature.com
Pulmonary hypertension (PH) is a cardiopulmonary disease characterized by a progressive
increase in pulmonary vascular resistance. One of the initial pathogenic factors of PH is …

Fetal lung regeneration using stem cell‐derived extracellular vesicles: A new frontier for pulmonary hypoplasia secondary to congenital diaphragmatic hernia

RL Figueira, L Antounians… - Prenatal …, 2022 - Wiley Online Library
The poor outcomes of babies with congenital diaphragmatic hernia (CDH) are directly
related to pulmonary hypoplasia, a condition characterized by impaired lung development …

Extracellular vesicles and their effect on vascular haemodynamics: a systematic review

SWY Cheung, LW Chamley, CJ Barrett… - Hypertension …, 2024 - nature.com
Extracellular vesicles (EVs) are released from all cell types studied to date and act as
intercellular communicators containing proteins, nucleic acids and lipid cargos. They have …

[HTML][HTML] Cellular origins and translational approaches to congenital diaphragmatic hernia

M Jank, F Doktor, A Zani, R Keijzer - Seminars in Pediatric Surgery, 2024 - Elsevier
Abstract Congenital Diaphragmatic Hernia (CDH) is a complex developmental abnormality
characterized by abnormal lung development, a diaphragmatic defect and cardiac …

The cellular and molecular effects of fetoscopic endoluminal tracheal occlusion in congenital diaphragmatic hernia

OO Olutoye II, WD Short, J Gilley… - Frontiers in …, 2022 - frontiersin.org
Congenital diaphragmatic hernia (CDH) is a complex disease associated with pulmonary
hypoplasia and pulmonary hypertension. Great strides have been made in our ability to care …

Fetal lung vascular development is disrupted by mechanical compression and rescued by administration of amniotic fluid stem cell extracellular vesicles via regulation …

RL Figueira, K Khalaj, L Antounians, F Doktor, MS Gaffi… - bioRxiv, 2023 - biorxiv.org
Postnatal pulmonary hypertension is the biggest treatment challenge and major determinant
for poor outcome in infants with congenital diaphragmatic hernia (CDH). CDH lungs are …

Single-cell transcriptomic profiling of microvascular endothelial cell heterogeneity in congenital diaphragmatic hernia

JO Robertson, P Bazeley, SC Erzurum, K Asosingh - Scientific Reports, 2023 - nature.com
Congenital diaphragmatic hernia (CDH) is a neonatal anomaly that includes pulmonary
hypoplasia and hypertension. We hypothesized that microvascular endothelial cell (EC) …