Neurodegenerative diseases are a common cause of morbidity and cognitive impairment in
older adults. Most clinicians who care for the elderly are not trained to diagnose these …

Amyotrophic lateral sclerosis is characterised by the progressive loss of motor neurons in
the brain and spinal cord. This neurodegenerative syndrome shares pathobiological …

Early reports of cognitive and behavioural deficits in motor neuron disease might have been
overlooked initially, but the concept of a frontotemporal dementia-motor neuron disease …

Increased awareness of cognitive and behavioural change in amyotrophic lateral sclerosis
has been driven by various clinic-based and population-based studies. A frontotemporal …

Patients with behavioural-variant frontotemporal dementia (bvFTD) present with insidious
changes in personality and interpersonal conduct that indicate progressive disintegration of …

The identification of a hexanucleotide repeat expansion in the C9ORF72 gene as the cause
of chromosome 9-linked frontotemporal dementia and motor neuron disease offers the …

An expanded hexanucleotide repeat in the C9ORF72 gene has recently been identified as a
major cause of familial frontotemporal lobar degeneration and motor neuron disease …

Frontotemporal lobar degeneration (FTLD) is the umbrella term encompassing a
heterogeneous group of pathological disorders. With recent discoveries, the FTLDs have …

Frontotemporal dementia and motor neuron disease share clinical, genetic and pathological
characteristics. Motor neuron disease develops in a proportion of patients with …

Frontotemporal dementia (FTD) is a focal clinical syndrome characterised by profound
changes in personality and social conduct and associated with circumscribed degeneration …