The endothelium can evoke relaxations of the underlying vascular smooth muscle, by
releasing vasodilator substances. The best‐characterized endothelium‐derived relaxing …

Intrarenal autoregulatory mechanisms maintain renal blood flow (RBF) and glomerular
filtration rate (GFR) independent of renal perfusion pressure (RPP) over a defined range (80 …

The heart is uniquely responsible for providing its own blood supply through the coronary
circulation. Regulation of coronary blood flow is quite complex and, after over 100 years of …

ROS are a group of small reactive molecules that play critical roles in the regulation of
various cell functions and biological processes. In the vascular system, physiological levels …

Rationale: Nitric oxide, the classic endothelium-derived relaxing factor (EDRF), acts through
cyclic GMP and calcium without notably affecting membrane potential. A major component of …

It has become clear that reactive oxygen species (ROS) contribute to the development of
hypertension via myriad effects. ROS are essential for normal cell function, however they …

Inflammation is a complex and potentially life-threatening condition that involves the
participation of a variety of chemical mediators, signaling pathways, and cell types. The …

The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the
blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in …

The endothelium, although only a single layer of cells lining the vascular and lymphatic
systems, contributes in multiple ways to vascular homeostasis. Subsequent to the 1980 …

Abstract Small arterioles (40–150 μm) contribute to the majority of vascular resistance within
organs and tissues. Under resting conditions, the basal tone of these vessels is determined …