Novel 1, 2, 4-oxadiazole derivatives in drug discovery
Five-membered 1, 2, 4-oxadiazole heterocyclic ring has received considerable attention
because of its unique bioisosteric properties and an unusually wide spectrum of biological …
because of its unique bioisosteric properties and an unusually wide spectrum of biological …
Design and Development of COX-II Inhibitors: Current Scenario and Future Perspective
Innate inflammation beyond a threshold is a significant problem involved in cardiovascular
diseases, cancer, and many other chronic conditions. Cyclooxygenase (COX) enzymes are …
diseases, cancer, and many other chronic conditions. Cyclooxygenase (COX) enzymes are …
Therapeutic potential of oxadiazole or furadiazole containing compounds
As we know that, Oxadiazole or furadi azole ring containing derivatives are an important
class of heterocyclic compounds. A heterocyclic five-membered ring that possesses two …
class of heterocyclic compounds. A heterocyclic five-membered ring that possesses two …
Visible-light 2, 4-dinitrophenol-mediated photoannulation of α-azidochalcones into 2, 5-diaryloxazoles
A novel and efficient visible-light 2, 4-dinitrophenol (2, 4-DNP) mediated photoannulation of
α-azidochalcones into 2, 5-diaryloxazoles was developed. The carbon–carbon double bond …
α-azidochalcones into 2, 5-diaryloxazoles was developed. The carbon–carbon double bond …
A comprehensive review of recent advances in the biological activities of 1, 2, 4‐oxadiazoles
OM Hendawy - Archiv der Pharmazie, 2022 - Wiley Online Library
Nitrogen heterocycles play an essential role in medication development. The 1, 2, 4‐
oxadiazole heterocycle has been extensively studied, yielding a large variety of molecules …
oxadiazole heterocycle has been extensively studied, yielding a large variety of molecules …
Tandem synthesis, antibacterial evaluation and SwissADME prediction study of new bis (1, 3, 4-oxadiazoles) linked to arene units
A three-component tandem protocol involving the reactions of bis (benzohydrazides),
aromatic aldehydes and chloramine trihydrate yielded a new series of bis (1, 3, 4 …
aromatic aldehydes and chloramine trihydrate yielded a new series of bis (1, 3, 4 …
New Arene and/or Heteroarene‐Linked 1, 3, 4‐Oxadiazoles: Synthesis of Potential Methicillin‐Resistant Staphylococcus aureus and Vancomycin‐Resistant …
AEM Mekky, RA Abdelbaath, RA Abdelbaath… - …, 2024 - Wiley Online Library
Bacterial infections, particularly those associated with methicillin‐resistant Staphylococcus
aureus (MRSA) and vancomycin‐resistant Enterococcus (VRE), threaten public health and …
aureus (MRSA) and vancomycin‐resistant Enterococcus (VRE), threaten public health and …
Structure-based screening for the discovery of 1, 2, 4-oxadiazoles as promising hits for the development of new anti-inflammatory agents interfering with eicosanoid …
M Potenza, M Sciarretta, MG Chini, A Saviano… - European Journal of …, 2021 - Elsevier
The multiple inhibition of biological targets involved in pro-inflammatory eicosanoid
biosynthesis represents an innovative strategy for treating inflammatory disorders in light of …
biosynthesis represents an innovative strategy for treating inflammatory disorders in light of …
Palladium catalyzed direct C–H arylation of 1, 3, 4-oxadiazole using ligand combination approach
SP Bakare, M Patil - Tetrahedron, 2024 - Elsevier
The use of combination of readily available ligands in palladium catalyzed C–H arylation of
1, 3, 4-oxadiazole with iodoarenes as well as bromoarenes is reported. The combination of …
1, 3, 4-oxadiazole with iodoarenes as well as bromoarenes is reported. The combination of …
Dissecting The role of Plasmodium metacaspase-2 in malaria gametogenesis and sporogony
The family of apicomplexan specific proteins contains caspases–like proteins called
“metacaspases”. These enzymes are present in the malaria parasite but absent in human; …
“metacaspases”. These enzymes are present in the malaria parasite but absent in human; …