Abstract The TFOS DEWS II Pathophysiology Subcommittee reviewed the mechanisms
involved in the initiation and perpetuation of dry eye disease. Its central mechanism is …

Mucus is a selective barrier to particles and molecules, preventing penetration to the
epithelial surface of mucosal tissues. Significant advances in transmucosal drug delivery …

Dry eye can damage the ocular surface and result in mild corneal epithelial defect to
blinding corneal pannus formation and squamous metaplasia. Significant progress in the …

The mucosal tissues of the gastrointestinal, respiratory, reproductive, and urinary tracts, and
the surface of the eye present an enormous surface area to the exterior environment. All of …

Sjögren's syndrome is a chronic autoimmune disorder of the exocrine glands with
associated lymphocytic infiltrates of the affected glands. Dryness of the mouth and eyes …

Goblet cells within the conjunctival epithelium are specialized cells that secrete mucins onto
the surface of the eye. Recent research has demonstrated new characteristics of the cells …

In the present update on mucoadhesive ocular dosage forms, the tremendous advances in
the biochemistry of mucins, the development of new polymers, the use of drug complexes …

The ocular surface, tear film, lacrimal glands, and eyelids act as a functional unit to preserve
the quality of the refractive surface of the eye and to resist injury and protect the eye against …

A key element of contact lens practice involves clinical evaluation of anterior eye health,
including the cornea and limbus, conjunctiva and sclera, eyelids and eyelashes, lacrimal …

Mucins are vital for maintenance of a healthy, wet ocular surface. Once only thought to be
secreted by goblet cells, mucins are now also known to be of the membrane-associated …