Nucleic acid tests for clinical translation
Nucleic acids, including deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), are
natural biopolymers composed of nucleotides that store, transmit, and express genetic …
natural biopolymers composed of nucleotides that store, transmit, and express genetic …
Functional nucleic acid biosensors utilizing rolling circle amplification
Functional nucleic acids (FNAs), including DNA aptamers and DNAzymes, are finding
increasing use as molecular recognition elements for point-of-care (POC) assays and …
increasing use as molecular recognition elements for point-of-care (POC) assays and …
Freezing directed construction of bio/nano interfaces: reagentless conjugation, denser spherical nucleic acids, and better nanoflares
While nanoparticle solutions cannot freeze in general, they may remain stable in the
presence of polymer stabilizers. We herein communicate that gold nanoparticles (AuNPs) …
presence of polymer stabilizers. We herein communicate that gold nanoparticles (AuNPs) …
Single-step, salt-aging-free, and thiol-free freezing construction of AuNP-based bioprobes for advancing CRISPR-based diagnostics
M Hu, C Yuan, T Tian, X Wang, J Sun… - Journal of the …, 2020 - ACS Publications
The recently reported freezing-based labeling method for constructing DNA-AuNP probes is
rapid but still requires thiol modification. Here, we evaluated a poly (A)-tagged DNA …
rapid but still requires thiol modification. Here, we evaluated a poly (A)-tagged DNA …
Flash synthesis of spherical nucleic acids with record DNA density
Y Hao, Y Li, L Song, Z Deng - Journal of the American Chemical …, 2021 - ACS Publications
Nanoparticles (NPs) decorated with a high density of DNA strands, also known as spherical
nucleic acids (SNAs), are widely used in DNA-programmable assembly, sensing, imaging …
nucleic acids (SNAs), are widely used in DNA-programmable assembly, sensing, imaging …
An exonuclease III‐powered, on‐particle stochastic DNA walker
DNA‐based machines have attracted rapidly growing interest owing to their potential in drug
delivery, biocomputing, and diagnostic applications. Herein, we report a type of exonuclease …
delivery, biocomputing, and diagnostic applications. Herein, we report a type of exonuclease …
Programming nanoparticle valence bonds with single-stranded DNA encoders
Nature has evolved strategies to encode information within a single biopolymer to program
biomolecular interactions with characteristic stoichiometry, orthogonality and …
biomolecular interactions with characteristic stoichiometry, orthogonality and …
Nanoparticle cellular internalization is not required for RNA delivery to mature plant leaves
Rapidly growing interest in the nanoparticle-mediated delivery of DNA and RNA to plants
requires a better understanding of how nanoparticles and their cargoes translocate in plant …
requires a better understanding of how nanoparticles and their cargoes translocate in plant …
Interface-driven hybrid materials based on DNA-functionalized gold nanoparticles
DNA-functionalized gold nanoparticles (AuNPs) are popular hybrid materials with
applications in directed assembly, biosensor development, and drug delivery. This system is …
applications in directed assembly, biosensor development, and drug delivery. This system is …
CRISPR/Cas12a-Derived electrochemical aptasensor for ultrasensitive detection of COVID-19 nucleocapsid protein
C Han, W Li, Q Li, W Xing, H Luo, H Ji, X Fang… - Biosensors and …, 2022 - Elsevier
Fast, affordable, portable, and sensitive technology to detect COVID-19 is critical to address
the current outbreak. Here, we present a CRISPR/Cas12a-derived electrochemical …
the current outbreak. Here, we present a CRISPR/Cas12a-derived electrochemical …