Significance: The detrimental effects of ionizing radiation (IR) involve a highly orchestrated
series of events that are amplified by endogenous signaling and culminating in oxidative …

The regulatory mechanisms by which hydrogen peroxide (H 2 O 2) modulates the activity of
transcription factors in bacteria (OxyR and PerR), lower eukaryotes (Yap1, Maf1, Hsf1 and …

Acetate is a major nutrient that supports acetyl-coenzyme A (Ac-CoA) metabolism and thus
lipogenesis and protein acetylation. However, its source is unclear. Here, we report that …

A cascade amplification release nanoparticle (CARN) is constructed by the coencapsulation
of β‐lapachone and a reactive‐oxygen‐species (ROS)‐responsive doxorubicin (DOX) …

Since the industrial revolution, the production, and consequently the emission of metals, has
increased exponentially, overwhelming the natural cycles of metals in many ecosystems …

Combining existing drug therapy is essential in developing new therapeutic agents in
disease prevention and treatment. In preclinical investigations, combined effect of certain …

The ataxia-telangiectasia mutated (ATM) protein kinase is activated by DNA double-strand
breaks (DSBs) through the Mre11-Rad50-Nbs1 (MRN) DNA repair complex and …

Chemodynamic therapy (CDT) is an emerging tumor microenvironment‐responsive cancer
therapeutic strategy based on Fenton/Fenton‐like reactions. However, the effectiveness of …

Hydrogen peroxide (H2O2) is a well-documented component of living cells. It plays
important roles in host defense and oxidative biosynthetic reactions. In addition there is …

Newly emerging fluorescence imaging in the second near‐infrared window (NIR‐II, 1000–
1700 nm) permits visualization of deep anatomical features with unprecedented spatial …