In mammals, hundreds of proteins use iron in a multitude of cellular functions, including vital
processes such as mitochondrial respiration, gene regulation and DNA synthesis or repair …

Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers. Significant
efforts have largely defined major genetic factors driving PDAC pathogenesis and …

Every cell must satisfy basic requirements for nutrient sensing, utilization and recycling
through macromolecular breakdown to coordinate programmes for growth, repair and stress …

Lysosomes are catabolic organelles that govern numerous cellular processes, including
macromolecule degradation, nutrient signalling and ion homeostasis. Aberrant changes in …

Macroautophagy is a cellular quality-control process that degrades proteins, protein
aggregates and damaged organelles. Autophagy plays a fundamental role in cancer where …

Pancreatic ductal adenocarcinoma (PDAC) cells maintain a high level of autophagy,
allowing them to thrive in an austere microenvironment. However, the processes through …

Although RAS was formerly considered undruggable, various agents that inhibit RAS or
specific RAS oncoproteins have now been developed. Indeed, the importance of directly …

Autophagy is a cellular homeostasis mechanism that fuels the proliferation and survival of
advanced cancers by degrading and recycling organelles and proteins. Preclinical studies …

Acute myeloid leukemia (AML) remains a challenging hematological malignancy with poor
prognosis and limited treatment options. Leukemic stem cells (LSCs) contribute to …

Pharmacological inhibition of KRAS> RAF> MEK1/2> ERK1/2 signaling has provided no
clinical benefit to patients with pancreatic ductal adenocarcinoma (PDAC). Interestingly …