MSCs: biological characteristics, clinical applications and their outstanding concerns

YL Si, YL Zhao, HJ Hao, XB Fu, WD Han - Ageing research reviews, 2011 - Elsevier
Mesenchymal stem cells (MSCs) are multi-potent adult stem cells harboring multi-lineage
differentiation potential and immunosuppressive properties that make MSCs an ideal …

Mesenchymal stem cells: angels or demons?

RSY Wong - BioMed Research International, 2011 - Wiley Online Library
Mesenchymal stem cells (MSCs) have been used in cell‐based therapy in various disease
conditions such as graft‐versus‐host and heart diseases, osteogenesis imperfecta, and …

Hypoxic preconditioning induces the expression of prosurvival and proangiogenic markers in mesenchymal stem cells

SM Chacko, S Ahmed, K Selvendiran… - … of Physiology-Cell …, 2010 - journals.physiology.org
Stem cells transplanted to the ischemic myocardium usually encounter massive cell death
within a few days of therapy. Hypoxic preconditioning (HPC) is currently employed as a …

[HTML][HTML] Mesenchymal stem cells: from experiment to clinic

WR Otto, NA Wright - Fibrogenesis & Tissue Repair, 2011 - Springer
There is currently much interest in adult mesenchymal stem cells (MSCs) and their ability to
differentiate into other cell types, and to partake in the anatomy and physiology of remote …

Cryopreservation of human mesenchymal stem cells for clinical applications: current methods and challenges

KW Yong, WKZ Wan Safwani, F Xu… - Biopreservation and …, 2015 - liebertpub.com
Mesenchymal stem cells (MSCs) hold many advantages over embryonic stem cells (ESCs)
and other somatic cells in clinical applications. MSCs are multipotent cells with strong …

Mesenchymal stem cells for cardiac cell therapy

YH Choi, A Kurtz, C Stamm - Human gene therapy, 2011 - liebertpub.com
Despite refinements of medical and surgical therapies, heart failure remains a fatal disease.
Myocardial infarction is the most common cause of heart failure, and only palliative …

Cryopreservation does not alter main characteristics of good manufacturing process–grade human multipotent mesenchymal stromal cells including …

J Luetzkendorf, K Nerger, J Hering, A Moegel… - Cytotherapy, 2015 - Elsevier
Background aims The immunomodulating capacity of multipotent mesenchymal stromal
cells (MSCs) qualifies them as a therapeutic tool in several diseases. However, repeated …

The effects of cryopreservation on cells isolated from adipose, bone marrow and dental pulp tissues

OG Davies, AJ Smith, PR Cooper, RM Shelton… - Cryobiology, 2014 - Elsevier
The effects of cryopreservation on mesenchymal stem cell (MSC) phenotype are not well
documented; however this process is of increasing importance for regenerative therapies …

[HTML][HTML] Efficacy of mesenchymal stem cell therapy in systolic heart failure: a systematic review and meta-analysis

M Fan, Y Huang, Z Chen, Y Xia, A Chen, D Lu… - Stem Cell Research & …, 2019 - Springer
Background Heart failure (HF) is the end stage of most heart disease. Mesenchymal stem
cells (MSCs), with their specific biological effects, have been applied in several clinical trials …

[HTML][HTML] Cryopreservation does not change the performance and characteristics of allogenic mesenchymal stem cells highly over-expressing a cytoplasmic therapeutic …

YK Ho, KM Loke, JY Woo, YL Lee, HP Too - Stem Cell Research & …, 2022 - Springer
Abstract Background Mesenchymal stem cells (MSCs) driven gene directed enzyme prodrug
therapy is a promising approach to deliver therapeutic agents to target heterogenous solid …