In recent years, lipid metabolism has garnered significant attention as it provides the
necessary building blocks required to sustain tumor growth and serves as an alternative fuel …

Despite the remarkable progress in cancer treatment up to now, we are still far from
conquering the disease. The most substantial change after the malignant transformation of …

Inhibition of de novo palmitate synthesis via fatty acid synthase (FASN) inhibition provides
an unproven approach to cancer therapy with a strong biological rationale. FASN …

The tumor cell changes itself and its microenvironment to adapt to different situations,
including action of drugs and other agents targeting tumor control. Therefore, metabolism …

Introduction: Cancer cells have increased glycolysis and glutaminolysis. Their third feature is
increased de novo lipogenesis. As such, fatty acid (FA) synthesis enzymes are over …

Ferroptosis, a new type of regulated cell death, displays characteristics that transparently
differ from apoptosis, autophagy and necroptosis. There is growing appreciation that …

Fatty acid synthase (FASN) is the biosynthetic enzyme responsible for the endogenous
synthesis of fatty acids. It is downregulated in most normal cells, except in lipogenic tissues …

Abstract Fatty acid synthase (EC 2.3. 1.85; FASN) is a multifunctional enzyme system that
catalyzes the formation of fatty acids from acetyl-CoA, malonyl-CoA, and NADPH and plays …

The immune function of normal T cells partially depends on the maneuvering of lipid
metabolism through various stages and subsets. Interestingly, T-cell malignancies also …

The redeployed drug combination of bezafibrate and medroxyprogesterone acetate
(designated BaP) has potent in vivo anticancer activity in acute myelogenous leukemia …