Folate plays a key role in the interactions between nutrition, fetal programming, and
epigenomics. Maternal folate status influences DNA methylation, inheritance of the agouti …

We continue to make progress in our understanding of the regulation of gastric acid
secretion in health and disease. A better understanding of the pathways and mechanisms …

Vitamin B12 (cobalamin, cbl) is a cofactor of methionine synthase (MTR) in the synthesis of
methionine, the precursor of the universal methyl donor S-Adenosylmethionine (SAM) …

Cardiomyopathies occur by mechanisms that involve inherited and acquired metabolic
disorders. Both folate and vitamin B12 deficiencies are associated with left ventricular …

Background Methyl donor deficiency (MDD) aggravates experimental colitis in rats and
increases endoplasmic reticulum (ER) stress through decreased sirtuin 1 (SIRT1) in …

Homocysteine in pregnancy Page 120 ADVANCES IN CLINICAL CHEMISTRY, VOL. 53
HOMOCYSTEINE IN PREGNANCY Michelle M. Murphy*,†, 1 and Joan D. Fernandez-Ballart*,† …

Ghrelin is predominantly produced by the gastric enteroendocrine cell compartment and is
octanoylated by the recently discovered ghrelin o-acyltransferase (GOAT) before secretion …

Barker's concept of 'foetal programming'proposes that intrauterine growth restriction (IUGR)
predicts complex metabolic diseases through relationships that may be further modified by …

The micronutrients folate and vitamin B12 are essential for the proper development of the
central nervous system, and their deficiency during pregnancy has been associated with a …

Scope Our study aims to investigate molecular events associated to methyl donor deficiency
(MDD) by analyzing the transcriptome and the methylome of MDD rats in liver. Methods and …