Unraveling the secrets: evolution of resistance mediated by membrane proteins

X Yang, M Li, ZC Jia, Y Liu, SF Wu, MX Chen… - Drug Resistance …, 2024 - Elsevier
Membrane protein-mediated resistance is a multidisciplinary challenge that spans fields
such as medicine, agriculture, and environmental science. Understanding its complexity and …

Integrons as the potential targets for combating multidrug resistance in Enterobacteriaceae using CRISPR- Cas9 technique

VP Shetty, SD Akshay, P Rai… - Journal of applied …, 2023 - academic.oup.com
The emergence of multi-drug resistance (MDR) to pan-drug resistance (PDR) in
Enterobacteriaceae has made treatment extremely challenging. Genetic mutations and …

Outer Membrane Proteins and Efflux Pumps Mediated Multi-Drug Resistance in Salmonella: Rising Threat to Antimicrobial Therapy

SD Akshay, VK Deekshit, J Mohan Raj… - ACS Infectious …, 2023 - ACS Publications
Despite colossal achievements in antibiotic therapy in recent decades, drug-resistant
pathogens have remained a leading cause of death and economic loss globally. One such …

Antimicrobial resistance: two-component regulatory systems and multidrug efflux pumps

GV De Gaetano, G Lentini, A Famà, F Coppolino… - Antibiotics, 2023 - mdpi.com
The number of multidrug-resistant bacteria is rapidly spreading worldwide. Among the
various mechanisms determining resistance to antimicrobial agents, multidrug efflux pumps …

Ciprofloxacin and Tetracycline Resistance Cause Collateral Sensitivity to Aminoglycosides in Salmonella Typhimurium

M Hasan, J Wang, J Ahn - Antibiotics, 2023 - mdpi.com
The objective of this study was to evaluate collateral sensitivity and cross-resistance of
antibiotic-induced resistant Salmonella Typhimurium to various antibiotics. S. Typhimurium …

Predicting Salmonella MIC and Deciphering Genomic Determinants of Antibiotic Resistance and Susceptibility

MB Ayoola, AR Das, BS Krishnan, DR Smith, B Nanduri… - Microorganisms, 2024 - mdpi.com
Salmonella spp., a leading cause of foodborne illness, is a formidable global menace due to
escalating antimicrobial resistance (AMR). The evaluation of minimum inhibitory …

Analysis of mcr family of colistin resistance genes in Gram-negative isolates from a tertiary care hospital in India

D Irusan, SD Akshay, VP Shetty… - Journal of Applied …, 2024 - academic.oup.com
Aim Colistin serves as the drug of last resort for combating numerous multidrug-resistant
(MDR) Gram-negative infections. Its efficacy is hampered by the prevalent issue of colistin …

Defying the odds: Determinants of the antimicrobial response of Salmonella Typhi and their interplay

AR Chowdhury, D Mukherjee… - Molecular …, 2024 - Wiley Online Library
Salmonella Typhi, the invasive serovar of S. enterica subspecies enterica, causes typhoid
fever in healthy human hosts. The emergence of antibiotic‐resistant strains has consistently …

Role and mechanism of the outer membrane porin LamB in T-2 mycotoxin-mediated extensive drug resistance in Escherichia coli

F Deng, L Zhao, P Wei, E Mai, M Chen, H Yang… - Journal of Hazardous …, 2024 - Elsevier
The influence of mycotoxins in ecological niches shared with antibiotic-resistant bacteria
(ARB) remains underexplored. This study examined the impact of T-2 mycotoxin on the …

Exposure to imipenem at sub-minimum inhibitory concentration leads to altered expression of major outer membrane proteins in Acinetobacter baumannii

S Nayak, SD Akshay, VK Deekshit… - Journal of Applied …, 2024 - academic.oup.com
Aims Acinetobacter baumannii is a nosocomial pathogen known to be multidrug-resistant
(MDR), especially to drugs of the carbapenem class. Several factors contribute to resistance …