Major depressive disorder is a growing and poorly understood pathology. Due to technical
and ethical limitations, a significant proportion of the research on depressive disorders …

Abstract Background Persons with Major Depressive Disorder (MDD), notably treatment-
resistant depression (TRD), are differentially affected by type 2 diabetes mellitus and …

Ketamine is the prototype of a new generation of antidepressant drugs, which is reported in
clinical studies to be effective in treatment-resistant patients, with an effect that appears …

Voltage-gated calcium channels (VGCCs) play a critical role in neuroinflammatory diseases,
such as multiple sclerosis (MS). CTK 01512-2 is a recombinant version of the peptide Phα1β …

The increased incidence of depression in women going through peri-menopause suggests
that fluctuations in estrogen levels may increase the risk of developing depression …

Objective Temporal lobe epilepsy (TLE) is one of the most common types of epilepsy
syndromes in the world. Depression is an important comorbidity of epilepsy, which has been …

The attribution of incentive-motivational value to reward-related cues contributes to cue-
induced craving and relapse in addicted patients. Recently, it was demonstrated that …

Ureases are microbial virulence factors either because of the enzymatic release of ammonia
or due to many other non-enzymatic effects. Here we studied two neurotoxic urease …

Acute treatment with ketamine, an NMDA receptor antagonist, has been reported to be
efficacious in treating depression. The goal of our study was to evaluate ketamine treatment …

This study was performed to evaluate the bilateral effects of focal permanent ischemia (FPI)
on glial metabolism in the cerebral cortex. Two and 9 days after FPI induction, we analyze …