Mechanisms of deep brain stimulation

TM Herrington, JJ Cheng… - Journal of …, 2016 - journals.physiology.org
Deep brain stimulation (DBS) is widely used for the treatment of movement disorders
including Parkinson's disease, essential tremor, and dystonia and, to a lesser extent, certain …

Oscillations and the basal ganglia: motor control and beyond

JS Brittain, P Brown - Neuroimage, 2014 - Elsevier
Oscillations form a ubiquitous feature of the central nervous system. Evidence is accruing
from cortical and sub-cortical recordings that these rhythms may be functionally important …

Synchronous oscillatory neural ensembles for rules in the prefrontal cortex

TJ Buschman, EL Denovellis, C Diogo, D Bullock… - Neuron, 2012 - cell.com
Intelligent behavior requires acquiring and following rules. Rules define how our behavior
should fit different situations. To understand its neural mechanisms, we simultaneously …

An update on best practice of deep brain stimulation in Parkinson's disease

CJ Hartmann, S Fliegen, SJ Groiss… - Therapeutic …, 2019 - journals.sagepub.com
During the last 30 years, deep brain stimulation (DBS) has evolved into the clinical standard
of care as a highly effective treatment for advanced Parkinson's disease. Careful patient …

Executive dysfunction

GD Rabinovici, ML Stephens… - … : Lifelong Learning in …, 2015 - journals.lww.com
Abstract Purpose of Review: Executive functions represent a constellation of cognitive
abilities that drive goal-oriented behavior and are critical to the ability to adapt to an ever …

Synchronized neural oscillations and the pathophysiology of Parkinson's disease

A Oswal, P Brown, V Litvak - Current opinion in neurology, 2013 - journals.lww.com
Oscillatory activities across multiple frequency bands and their cross-frequency interactions
within spatially segregated loops of the basal ganglia-thalamo-cortical system may relate to …

Neural mechanisms resolving exploitation-exploration dilemmas in the medial prefrontal cortex

P Domenech, S Rheims, E Koechlin - Science, 2020 - science.org
INTRODUCTION Everyday life often requires arbitrating between pursuing an ongoing
action plan by possibly adjusting it versus exploring new action plans instead. Resolving this …

Why do we move to the beat? A multi-scale approach, from physical principles to brain dynamics

L Damm, D Varoqui, VC De Cock, S Dalla Bella… - Neuroscience & …, 2020 - Elsevier
Humans' ability to synchronize movement with auditory rhythms relies on motor networks,
such as cortical areas, basal ganglia and the cerebellum, which also participate in rhythm …

The highs and lows of beta activity in cortico‐basal ganglia loops

JS Brittain, A Sharott, P Brown - European Journal of …, 2014 - Wiley Online Library
Oscillatory activity in the beta (13–30 H z) frequency band is widespread in cortico‐basal
ganglia circuits, and becomes prominent in Parkinson's disease (PD). Here we develop the …

Mechanisms underlying decision-making as revealed by deep-brain stimulation in patients with Parkinson's disease

DM Herz, S Little, DJ Pedrosa, G Tinkhauser… - Current Biology, 2018 - cell.com
To optimally balance opposing demands of speed and accuracy during decision-making, we
must flexibly adapt how much evidence we require before making a choice. Such …