Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …

Caspases are a family of conserved cysteine proteases that play key roles in programmed
cell death and inflammation. In multicellular organisms, caspases are activated via …

Caspases are an evolutionary conserved family of cysteine proteases that are centrally
involved in cell death and inflammation responses. A wealth of foundational insight into the …

Caspases are proteolytic enzymes that belong to the cysteine protease family and play a
crucial role in homeostasis and programmed cell death. Caspases have been broadly …

Caspases are a family of endoproteases that provide critical links in cell regulatory networks
controlling inflammation and cell death. The activation of these enzymes is tightly controlled …

TNF blockers are highly efficacious at dampening inflammation and reducing symptoms in
rheumatic diseases such as rheumatoid arthritis, psoriatic arthritis and ankylosing …

Programmed cell death is a distinct genetic and biochemical pathway essential to
metazoans. An intact death pathway is required for successful embryonic development and …

In the last decade, basic cancer research has produced remarkable advances in our
understanding of cancer biology and cancer genetics. Among the most important of these …

The demonstration of protein sequence and functional homology of the Caenorhabditis
elegans programmed cell death gene product, CED-3, with human caspase-1 in 1993 …

The core effectors of apoptosis encompass proteolytic enzymes of the caspase family, which
reside as latent precursors in most nucleated metazoan cells. A majority of studies on …