Human germ cell tumours (GCTs) are derived from stem cells of the early embryo and the
germ line. They occur in the gonads (ovaries and testes) and also in extragonadal sites …

The laboratory culture of human stem cells seeks to capture a cellular state as an in vitro
surrogate of a biological system. For the results and outputs from this research to be …

Naïve human pluripotent stem cells (hPSCs) provide a unique experimental platform of cell
fate decisions during pre-implantation development, but their lineage potential remains …

Studying the function of common genetic variants in primary human tissues and during
development is challenging. To address this, we use an efficient multiplexing strategy to …

Abstract Good Cell and Tissue Culture Practice (GCCP) 2.0 is an updated guidance
document from GCCP 1.0 (published by ECVAM in 2005), which was developed for practical …

Histone crotonylation is a non-acetyl histone lysine modification that is as widespread as
acetylation. However, physiological functions associated with histone crotonylation remain …

Current (high throughput omics-based) data support the model that human (malignant) germ
cell tumors are not initiated by somatic mutations, but, instead through a defined locked …

In the 20 years since human embryonic stem cells, and subsequently induced pluripotent
stem cells, were first described, it has become apparent that during long-term culture these …

Mesenchymal stem cells (MSCs) have been shown to be efficacy to attenuating
cardiovascular inflammation; however, there are many limitations to stem cell treatment …

Breast milk is chock-full of nutrients, immunological factors, and cells that aid infant
development. Maternal cells are the least studied breast milk component, and their unique …