Until recently, radiation effects have been considered to be mainly due to nuclear DNA
damage and their management by repair mechanisms. However, molecular biology studies …

Clustered DNA lesions, also called Multiply Damaged Sites, is the hallmark of ionizing
radiation. It is defined as the combination of two or more lesions, comprising strand breaks …

The linear-quadratic model is one of the key tools in radiation biology and physics. It
provides a simple relationship between cell survival and delivered dose:, and has been …

Cellular effects of ionizing radiation (IR) are of great variety and level, but they are mainly
damaging since radiation can perturb all important components of the cell, from the …

Detrimental effects of ionizing radiation (IR) are correlated to the varying efficiency of IR to
induce complex DNA damage. A double strand break (DSB) can be considered the simpler …

Radiotherapy (ionising radiation; IR) is utilised in the treatment of~ 50% of all human
cancers, and where the therapeutic effect is largely achieved through DNA damage …

Photons, such as X-or γ-rays, induce DNA damage (distributed throughout the nucleus) as a
result of low-density energy deposition. In contrast, particle irradiation with high linear …

The purpose of this study was to identify the roles of non-homologous end-joining (NHEJ) or
homologous recombination (HR) pathways in repairing DNA double-strand breaks (DSBs) …

Low-and high-linear energy transfer (LET) ionising radiation are effective cancer therapies,
but produce structurally different forms of DNA damage. Isolated DNA damage is repaired …

Biological effects of high-LET (linear energy transfer) radiation have received increasing
attention, particularly in the context of more efficient radiotherapy and space exploration …