Telomere replication: solving multiple end replication problems
E Bonnell, E Pasquier, RJ Wellinger - Frontiers in Cell and …, 2021 - frontiersin.org
Eukaryotic genomes are highly complex and divided into linear chromosomes that require
end protection from unwarranted fusions, recombination, and degradation in order to …
end protection from unwarranted fusions, recombination, and degradation in order to …
Structures of the human CST-Polα–primase complex bound to telomere templates
The mammalian DNA polymerase-α–primase (Polα–primase) complex is essential for DNA
metabolism, providing the de novo RNA–DNA primer for several DNA replication pathways …
metabolism, providing the de novo RNA–DNA primer for several DNA replication pathways …
Dynamic DNA binding, junction recognition and G4 melting activity underlie the telomeric and genome-wide roles of human CST
Abstract Human CST (CTC1–STN1–TEN1) is a ssDNA-binding complex that helps resolve
replication problems both at telomeres and genome-wide. CST resembles Replication …
replication problems both at telomeres and genome-wide. CST resembles Replication …
Mammalian CST averts replication failure by preventing G-quadruplex accumulation
M Zhang, B Wang, T Li, R Liu, Y Xiao… - Nucleic acids …, 2019 - academic.oup.com
Abstract Human CST (CTC1-STN1-TEN1) is an RPA-like complex that associates with G-
rich single-strand DNA and helps resolve replication problems both at telomeres and …
rich single-strand DNA and helps resolve replication problems both at telomeres and …
CTC1-mediated C-strand fill-in is an essential step in telomere length maintenance
X Feng, SJ Hsu, C Kasbek, M Chaiken… - Nucleic acids …, 2017 - academic.oup.com
To prevent progressive telomere shortening as a result of conventional DNA replication, new
telomeric DNA must be added onto the chromosome end. The de novo DNA synthesis …
telomeric DNA must be added onto the chromosome end. The de novo DNA synthesis …
Exploring the structural landscape of DNA maintenance proteins
Evolutionary annotation of genome maintenance (GM) proteins has conventionally been
established by remote relationships within protein sequence databases. However, often no …
established by remote relationships within protein sequence databases. However, often no …
CTC1 OB-B interaction with TPP1 terminates telomerase and prevents telomere overextension
H Wang, T Ma, X Zhang, W Chen, Y Lan… - Nucleic Acids …, 2023 - academic.oup.com
Abstract CST (CTC1-STN1-TEN1) is a telomere associated complex that binds ssDNA and
is required for multiple steps in telomere replication, including termination of G-strand …
is required for multiple steps in telomere replication, including termination of G-strand …
CTC1-STN1 terminates telomerase while STN1-TEN1 enables C-strand synthesis during telomere replication in colon cancer cells
Telomerase elongates the telomeric G-strand to prevent telomere shortening through
conventional DNA replication. However, synthesis of the complementary C-strand by DNA …
conventional DNA replication. However, synthesis of the complementary C-strand by DNA …
[HTML][HTML] Emerging roles of CST in maintaining genome stability and human disease
JA Stewart, Y Wang, SM Ackerson… - Frontiers in bioscience …, 2018 - ncbi.nlm.nih.gov
Abstract The human CTC1-STN1-TEN1 (CST) complex is a single-stranded DNA binding
protein that shares homology with RPA and interacts with DNA polymerase alpha/primase …
protein that shares homology with RPA and interacts with DNA polymerase alpha/primase …